Subcutaneous rheumatoid nodules
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At the time the article was created Vinicius Carraro do Nascimento had no recorded disclosures.View Vinicius Carraro do Nascimento's current disclosures
At the time the article was last revised Rohit Sharma had no recorded disclosures.View Rohit Sharma's current disclosures
Subcutaneous rheumatoid nodules are the most common extra-articular manifestation of rheumatoid arthritis, occurring in up to 40% of patients. They are universally associated with a positive rheumatoid factor (RF) 1.
The size of the nodules varies from 2 mm to 5 cm; they are firm, non-tender, and movable in subcutaneous tissue 2. They usually are seen in the subcutaneous plane of the forearm, elbows, occiput, and lumbosacral area 3.
Rheumatoid nodules are characterized histologically by a core of fibrinoid necrosis with surrounding palisading histiocytes and granulation tissue.