Supratentorial ependymoma

Supratentorial ependymomas are a type of location-specific ependymoma. They account for 30% of ependymomas, and in most instances are within or abutting the ventricles (third and fourth ventricles). In approximately 40% of cases they are remote from the ventricular surface, located within the parenchyma of the hemispheres. 

They usually present with headache, seizures and focal neurological deficits compared to infratentorial counterparts which mainly present with features of raised intracranial pressure.

Share similar pathological spectrum to posterior fossa ependymomas, with the exception that the RELA fusion-positive ependymoma subtype is usually supratentorial, and not found in the posterior fossa 7

Radiologically they are similar to ependymomas in other locations.

  • coarse calcification is common (50%) 
  • cystic areas (50%) 
  • solid component iso to hypodense
  • heterogeneous enhancement 
  • a small proportion can have haemorrhage
  • T1
    • solid portions of ependymoma typically are isointense to hypointense relative to white matter 7
  • T2
    • hyperintense to white matter
    • more reliable in differentiating tumour margins than non-contrast T1-weighted images (but less reliable than contrast enhanced T1)
  • T2* (e.g. SWI)
    • foci of blooming from haemorrhage of calcification
  • T1 C + (Gd)
    • enhancement present but heterogeneous
    • enhancement with gadolinium is useful in differentiating tumour from adjacent vasogenic oedema and normal brain parenchyma
  • DWI/ADC
    • restricted diffusion may be seen in solid components especially in anaplastic tumour
    • diffusion should be interpreted with caution in masses with significant haemorrhage or calcification

Supratentorial ependymomas generally have a somewhat better prognosis than their more common posterior fossa counterparts. This is especially the case in children 7

Imaging differential considerations depend on whether the tumour is within the ventricle or parenchymal.

For intraventricular supratentorial tumours consider: 

For parenchymal tumours consider: 

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Article information

rID: 25239
Section: Pathology
Synonyms or Alternate Spellings:
  • Supratentorial ependymomas

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Cases and figures

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    Case 1: intraventricular
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    Case 2
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    Case 3: intraventricular
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    Case 4: paranchymal
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