Citation, DOI & article data
Synaptophysin is a membrane glycoprotein found in presynaptic vesicles and is commonly used as an immunohistochemical marker for cells of neuronal (e.g. gangliogliomas) and neuroendocrine lineage (e.g. pheochromocytomas and paragangliomas) 1,2.
In the brain, it has been suggested that perisomatic synaptophysin immunohistochemical staining is not seen in normal neurons and therefore is a reliable feature to distinguish neoplastic from non-neoplastic neurons. It appears, however, that this is not always the case; normal brain, as well as non-neoplastic brain tissue, can show synaptophysin staining 3.
- 1. Wiedenmann B, Franke WW, Kuhn C, Moll R, Gould VE. Synaptophysin: a marker protein for neuroendocrine cells and neoplasms. Proceedings of the National Academy of Sciences of the United States of America. 83 (10): 3500-4. Pubmed
- 2. Miettinen M. Synaptophysin and neurofilament proteins as markers for neuroendocrine tumors. Archives of pathology & laboratory medicine. 111 (9): 813-8. Pubmed
- 3. Quinn B. Synaptophysin staining in normal brain: importance for diagnosis of ganglioglioma. The American journal of surgical pathology. 22 (5): 550-6. Pubmed