Synucleinopathies are a subgroup of neurodegenerative diseases, characterized by impairment of alpha-synuclein metabolism, resulting in abnormal intracellular deposits and can further be divided into those with and those without the formation of Lewy bodies 1,2:


α-synuclein is a neuronal protein of unclear function which accounts for approximately 1% of brain weight 1.

In addition to cerebral accumulation, α-synuclein also accumulates in the gastrointestinal tract resulting in symptoms 3

Editor: more detail is required here pertaining to the genetic and biochemical underpinnings of these diseases, as well as any commonalities in presentation/demographics/ radiographic appearances. 

Neurodegenerative diseases

Neurodegenerative diseases are legion and their classification just as protean. A useful approach is to divide them according to underlying pathological process, although even using this schema, there is much overlap and thus resulting confusion.

Article information

rID: 13002
Synonyms or Alternate Spellings:
  • Synucleinopathies

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