Last revised by Frank Gaillard on 26 Jul 2022

Synucleinopathies are a subgroup of neurodegenerative diseases, characterized by impairment of alpha-synuclein metabolism, resulting in abnormal intracellular deposits. They can further be divided into those with and those without the formation of Lewy bodies, although it should be noted that some overlap does exist 1,2,4:


α-synuclein is a neuronal protein of unclear function which accounts for approximately 1% of brain weight 1.

In addition to cerebral accumulation, α-synuclein also accumulates in the gastrointestinal tract resulting in symptoms 3

Editor: more detail is required here pertaining to the genetic and biochemical underpinnings of these diseases, as well as any commonalities in presentation/demographics/ radiographic appearances. 

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