Citation, DOI & article data
Synucleinopathies are a subgroup of neurodegenerative diseases, characterized by impairment of alpha-synuclein metabolism, resulting in abnormal intracellular deposits. They can further be divided into those with and those without the formation of Lewy bodies, although it should be noted that some overlap does exist 1,2,4:
- synucleinopathies with Lewy bodies
- synucleinopathies without Lewy bodies
α-synuclein is a neuronal protein of unclear function which accounts for approximately 1% of brain weight 1.
In addition to cerebral accumulation, α-synuclein also accumulates in the gastrointestinal tract resulting in symptoms 3.
Editor: more detail is required here pertaining to the genetic and biochemical underpinnings of these diseases, as well as any commonalities in presentation/demographics/ radiographic appearances.
- 1. Kornienko VN, Pronin IN. Diagnostic Neuroradiology. Springer Verlag. (2008) ISBN:3540756523. Read it at Google Books - Find it at Amazon
- 2. Taylor JP, O'Brien J. Neuroimaging of dementia with Lewy bodies. Neuroimaging Clin. N. Am. 2012;22 (1): 67-81, viii. doi:10.1016/j.nic.2011.11.001 - Pubmed citation
- 3. Kunal P. Patel, David T. Wymer, Vinay K. Bhatia, Ranjan Duara, Chetan D. Rajadhyaksha. Multimodality Imaging of Dementia: Clinical Importance and Role of Integrated Anatomic and Molecular Imaging. (2020) RadioGraphics. 40 (1): 200-222. doi:10.1148/rg.2020190070 - Pubmed
- 4. Jellinger K. More Frequent Lewy Bodies but Less Frequent Alzheimer-Type Lesions in Multiple System Atrophy as Compared to Age-Matched Control Brains. Acta Neuropathol. 2007;114(3):299-303. doi:10.1007/s00401-007-0227-4 - Pubmed