Systemic inflammatory response syndrome

Systemic inflammatory response syndrome (SIRS) refers to a physiological state in patients with a critical non-infectious or infectious illness. It is non-specific and although commonly associated with sepsis can be seen in many life-threatening illnesses.

Two or more of the features below are by definition present 1:

  • fever (greater than 38 degrees Celsius) or hypothermia (less than 36 degrees Celsius)
  • heart rate of over 90 beats per minute
  • respiratory rate over 20 breaths per minute or an arterial CO2 less than 32 mmHg
  • white-cell count over 12⨉109 cells/L, under 4⨉109 cells/L, or containing over 10% band forms

Conditions capable of producing SIRS include 2:

The definition of SIRS was created during the 1992 meeting of the American College of Chest Physicians and the Society of Critical Care Medicine 1

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Article information

rID: 60623
Synonyms or Alternate Spellings:
  • Systemic inflammatory response syndrome
  • SIRS

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