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At the time the article was created Prashant Mudgal had no recorded disclosures.View Prashant Mudgal's current disclosures
At the time the article was last revised Henry Knipe had the following disclosures:
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- Integral Diagnostics, Shareholder (ongoing)
- Micro-X Ltd, Shareholder (ongoing)
These were assessed during peer review and were determined to not be relevant to the changes that were made.View Henry Knipe's current disclosures
For the phenomenon to occur a particular combination of ADC and T2 signal intensity is required:
increased T2 signal
facilitated diffusion (high ADC values)
Remembering that the signal of diffusion weighted images is the result of both diffusion and T2 signal, it becomes apparent that if the amount of expected T2 shine through from the increased T2 signal is balanced by elevated ADC values (which would result in lower DWI signal intensity), then DWI signal may appear normal 1-3.
T2 washout should not be confused with related phenomena in ischemic stroke; early DWI reversal, seen acutely (typically 3-6 hours) and ADC pseudonormalization seen somewhat later (around 1 week post stroke) but before T2 washout, which occurs between 10-15 days typically.