Talcosis

Last revised by Dr Joshua Yap on 18 Jul 2022

Talcosis is a type of pneumoconiosis and can be prevalent in intravenous drug users. It is one of the four recognized types of talc-induced lung disease.

Talc (magnesium silicate) is used in the preparation of tablets intended for oral use, where it acts as a 'filler' and lubricant. When these tablets are ground down, dissolved and injected for illicit use, the talc accumulates in the pulmonary circulation. These deposits result in small foreign body reaction granulomas, which are birefringent under polarized light. If use is persistent the nodules can coalesce to form larger masses.

Intrinsically hyperdense micronodules (<1 mm) can be visible on CT.

ADVERTISEMENT: Supporters see fewer/no ads

Updating… Please wait.

 Unable to process the form. Check for errors and try again.

 Thank you for updating your details.