Tamm-Horsfall proteins, also known as uromodulin, may be a cause of echogenic renal pyramids in a neonate.
Tamm-Horsfall proteins are physiologically excreted by the renal tubular epithelium. They are most often encountered on neonatal renal ultrasound, where the concentrated proteins in the renal pyramids may mimic nonobstructing renal stones 1. It is considered a normal finding 2.
- 1. Durr-E-Sabih, Khan AN, Craig M et-al. Sonographic mimics of renal calculi. J Ultrasound Med. 2004;23 (10): 1361-7. J Ultrasound Med (full text) - Pubmed citation
- 2. Riebel TW, Abraham K, Wartner R et-al. Transient renal medullary hyperechogenicity in ultrasound studies of neonates: is it a normal phenomenon and what are the causes?. J Clin Ultrasound. 1993;21 (1): 25-31. Pubmed citation