Fukuoka consensus guidelines

Dr Dan J Bell and Dr Matt A. Morgan et al.

The Tanaka criteria, also referred to as the Fukuoka consensus guidelines, is a classification system for intraductal papillary mucinous neoplasms (IPMNs) and mucinous cystic neoplasms (MCNs)

The prior international consensus guidelines (2006) were referred to as the Sendai criteria, which later evolved into the Fukuoka consensus guidelines (2012) 1 with the latest update published in 2017 3

  • cyst <5 mm
    • asymptomatic: invasive carcinoma is rare if the patient is asymptomatic, therefore, follow-up only is recommended
    • symptomatic: further evaluation or resection (clinical circumstances dictate)
  • cyst >5 mm
    • pancreatic protocol CT or MRI pancreas and MRCP to evaluate
  • branch duct IPMN (BD-IPMN)
    • cyst >5mm communicating with main duct
  • main duct IPMN (MD-IPMN)
    • higher frequency of malignancy
    • dilatation of the main duct > 5 mm without other cause for obstruction
      • 5-9 mm: "worrisome feature"
      • ≥10 mm: "high-risk stigmata"
  • mixed-type IPMN: appears like an advanced branch duct IPMN with main pancreatic duct dilatation (>5 mm)
    • higher frequency of malignancy, similar to the main duct type
  • cyst ≥3 cm
  • thickened and enhancing cyst wall
  • enhancing mural nodule <5 mm
  • main pancreatic duct 5-9 mm
  • lymphadenopathy
  • abrupt change in calibre of pancreatic duct with distal pancreatic atrophy
  • cyst growth rate ≥5 mm in two years
  • elevated Ca19-9
  • gastric type: the majority of BD-IPMNs
  • intestinal type
  • pancreaticobiliary type
  • oncocytic type
  • resection
  • endoscopic ultrasound (EUS)
    • cysts with worrisome features
    • all cysts ≥3 cm without worrisome features
      • if inconclusive, then close surveillance with alternating MRI and EUS every 3-6 months
      • strongly consider surgery in young patients

Cyst fluid analysis is optional in a centre with expertise in EUS fine needle aspiration.

Optimal imaging surveillance strategies for suspected BD-IPMNs <3 cm and without worrisome features is unclear, but the yearly incidence of transformation to pancreatic cancer is estimated at 0.4-1.1% per year:

  • largest cyst <1 cm: CT or MRI/MRCP in 2-3 years
  • largest cyst 1-2 cm: CT or MRI/MRCP annually for 2 years, then lengthen interval if no change
  • largest cyst 2-3 cm: EUS in 6 months, then lengthen interval alternating MRI with EUS as appropriate
    • consider surgery in young patients

NB The American Gastroenterological Association recommends stopping surveillance after 5 years if no significant change is observed or if a cyst is resected and found to be benign 2. This is not a recommendation that is explicitly stated in the Fukuoka 2017 update 3.

Pancreatic pathology
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Article information

rID: 35423
Synonyms or Alternate Spellings:
  • International consensus guidelines for the management of IPMN and MCN of the pancreas (2012)
  • Fukuoka consensus guidelines
  • Sendai criteria
  • Tanaka criteria
  • Tanaka criteria for the management of IPMN and MCN of the pancreas (2012)

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