Target sign (cholangiocarcinoma)

Last revised by Dr Daniel J Bell on 29 Jan 2021

The target sign of cholangiocarcinoma refers to the appearance of intrahepatic mass-forming cholangiocarcinoma on DWI consisting of a centrally hypointense area and peripherally hyperintense rim. The presence of this sign favors cholangiocarcinoma over hepatocellular carcinoma. It is present in 57-83% of intrahepatic cholangiocarcinomas compared to 3-15% of hepatocellular carcinoma 1-3. A targetoid appearance of cholangiocarcinoma has also been described on hepatobiliary phase images after gadoxetate administration 2,4 and conventional T2 weighted images 5,6. The central portion of tumor corresponds to more fibrotic stroma.

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