Tc-99m DTPA
Last revised by Yvette Mellam
on 27 Feb 2023
Citation, DOI, disclosures and article data
Citation:
Jones J, Mellam Y, Sciacca F, et al. Tc-99m DTPA. Reference article, Radiopaedia.org (Accessed on 08 Dec 2024) https://doi.org/10.53347/rID-13610
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rID:
13610
Article created:
Disclosures:
At the time the article was created Jeremy Jones had no recorded disclosures.
View Jeremy Jones's current disclosures
Last revised:
27 Feb 2023,
Yvette Mellam
Disclosures:
At the time the article was last revised Yvette Mellam had no financial relationships to ineligible companies to disclose.
View Yvette Mellam's current disclosures
Revisions:
11 times, by
8 contributors -
see full revision history and disclosures
Systems:
Synonyms:
- Technetium-99m diethylene-triamine-pentaacetate (DTPA)
- DTPA
- Technetium-99m diethylene-triamine-pentaacetate
- Tc-99m diethylene-triamine-pentaacetate
- Tc-99m labelled diethylenetriaminepentaacetate
Tc-99m DTPA (diethylene-triamine-pentaacetate) is one of the technetium radiopharmaceuticals used in renal imaging and primarily used to measure the glomerular filtration rate (GFR).
Characteristics
photon energy: 140 KeV
physical half-life: 6 hours
oxidation state of technetium: +4
biological half-life: 2.5 hours
normal distribution: kidneys (100%)
-
pharmacokinetics
uptake by glomerular filtration (100%)
first pass filtration: 10-20%
excretion: renal; cleared only via glomeruli with no tubular excretion. Thus making it available for direct measurement of GFR.
target organ: bladder
-
miscellaneous facts:
poor quality images with renal insufficiency
Uses, doses and timings
adult dose: 200 MBq (about 3 MBq per kg of body weight)
60 sec flow study; then every 5 minutes for 25 minutes
Quiz questions
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References
- Taylor A & Nally J. Clinical Applications of Renal Scintigraphy. AJR Am J Roentgenol. 1995;164(1):31-41. doi:10.2214/ajr.164.1.7998566 - Pubmed
Incoming Links
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