Tc-99m DTPA

Last revised by Francesco Sciacca on 05 Oct 2022

Tc-99m DTPA (diethylene-triamine-pentaacetate) is one of the technetium radiopharmaceuticals used in renal imaging and primarily used to measure the glomerular filtration rate (GFR).

Characteristics

  • photon energy: 140 KeV
  • physical half-life: 6 hours
  • oxidation state of technetium: +4
  • biological half-life: 2.5 hours
  • normal distribution: kidneys (100%)
  • pharmacokinetics
    • uptake by glomerular filtration (100%)
    • first pass filtration: 10-20%
  • excretion: renal; cleared only via glomeruli with no tubular excretion. Thus making it available for direct measurement of GFR.
  • target organ: bladder
  • miscellaneous facts:
    • poor quality images with renal insufficiency

Uses, doses and timings

  • dynamic renal scintigraphy
  • adult dose: 200 MBq (about 3 MBq per kg of body weight)
  • 60 sec flow study; then every 5 minutes for 25 minutes

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