Tc-99m DTPA

Last revised by Yvette Mellam on 27 Feb 2023

Tc-99m DTPA (diethylene-triamine-pentaacetate) is one of the technetium radiopharmaceuticals used in renal imaging and primarily used to measure the glomerular filtration rate (GFR).


  • photon energy: 140 KeV

  • physical half-life: 6 hours

  • oxidation state of technetium: +4

  • biological half-life: 2.5 hours

  • normal distribution: kidneys (100%)

  • pharmacokinetics

    • uptake by glomerular filtration (100%)

    • first pass filtration: 10-20%

  • excretion: renal; cleared only via glomeruli with no tubular excretion. Thus making it available for direct measurement of GFR.

  • target organ: bladder

  • miscellaneous facts:

    • poor quality images with renal insufficiency

Uses, doses and timings

  • dynamic renal scintigraphy

  • adult dose: 200 MBq (about 3 MBq per kg of body weight)

  • 60 sec flow study; then every 5 minutes for 25 minutes

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