Tc-99m HMPAO labeled WBC
Citation, DOI, disclosures and article data
Citation:
Murphy A, Sciacca F, Bell D, et al. Tc-99m HMPAO labeled WBC. Reference article, Radiopaedia.org (Accessed on 14 Jan 2025) https://doi.org/10.53347/rID-15561
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rID:
15561
Article created:
26 Oct 2011,
The Radswiki ◉
Disclosures:
At the time the article was created The Radswiki had no recorded disclosures.
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Last revised:
Disclosures:
At the time the article was last revised Andrew Murphy had no recorded disclosures.
View Andrew Murphy's current disclosures
Revisions:
8 times, by
5 contributors -
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Synonyms:
- Tc-99m hexamethylpropyleneamine oxime labelled WBC
- Technecium 99m HMPAO labelled WBC
Tc-99m HMPAO (hexamethylpropyleneamine oxime) labeled WBC is one of the technetium radiopharmaceuticals used in WBC imaging.
There are three potential radiochemical impurities in the 99mTc-HMPAO: a hydrophilic secondary complex, the free pertechnetate and the reduced 99mTc-hydrolyzate. 1The minimum expected radiochemical purity is approximately 80%.
Characteristics
- photon energy: 140 KeV
- physical half life: 6 hours
- biological half life: 4 hours
- molecular geometry: square pyramidal
- normal distribution: spleen, liver, kidney, bone marrow
- pharmacokinetics: radiolabel in vitro
- excretion: hepatobiliary, renal
- target organ: colon, bladder, spleen
- miscellaneous facts:
- lipophilic: crosses cell membranes and the blood brain barrier; bound to mitochondria and the nucleus within cells
- better image quality and lower radiation dose than In-111 WBC
- high false positive rate for spine infection (Ga-67 may be preferable)
Uses, doses and timings
- infection
- adult dose: 370 MBq (10 mCi) IV
- timing: 2 hours for abdominal
- timing: 4 hours for skeletal (30 min whole body acquisition, 10 min spots)
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References
- 1. M. P. Natale. P&C 5.1. Tecnico di radiologia. Guida completa alla preparazione di test preselettivi e prove pratiche per TSRM. Con software di simulazione. (2019) ISBN: 9788865846483
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