Tc-99m HMPAO labelled WBC

Dr Jeremy Jones and Radswiki et al.

Tc-99m HMPAO (hexamethylpropyleneamine oxime) labelled WBC is one of the technetium radiopharmaceuticals used in WBC imaging.

Characteristics

  • photon energy: 140 KeV
  • physical half life: 6 hours
  • biological half life: 4 hours
  • normal distribution: spleen, liver, kidney, bone marrow
  • pharmacokinetics: radiolabel in vitro
  • excretion: hepatobiliary, renal
  • target organ: colon, bladder, spleen
  • miscellaneous facts:
    • lipophilic: crosses cell membranes and the blood brain barrrier; bound to mitochondria and the nucleus within cells
    • better image quality and lower radiation dose than In-111 WBC
    • high false positive rate for spine infection (Ga-67 may be preferable)

Uses, doses and timings

  • Infection
    • adult dose: 10 mCi IV
    • timing: 2 hours for abdominal
    • timing: 4 hours for skeletal (30 min whole body acquisition, 10 min spots)
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Article information

rID: 15561
Section: Physics
Synonyms or Alternate Spellings:
  • Tc-99m hexamethylpropyleneamine oxime labelled WBC
  • Technecium 99m HMPAO labelled WBC

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