Tc-99m MAA
Last revised by Liz Silverstone on 14 Sep 2023
Citation, DOI, disclosures and article data
Citation:
Radswiki T, Silverstone L, Chieng R, et al. Tc-99m MAA. Reference article, Radiopaedia.org (Accessed on 09 Oct 2024) https://doi.org/10.53347/rID-15562
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rID:
15562
Article created:
26 Oct 2011,
The Radswiki ◉
Disclosures:
At the time the article was created The Radswiki had no recorded disclosures.
View The Radswiki's current disclosures
Last revised:
Disclosures:
At the time the article was last revised Liz Silverstone had no financial relationships to ineligible companies to disclose.
View Liz Silverstone's current disclosures
Revisions:
9 times, by
8 contributors -
see full revision history and disclosures
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Synonyms:
- Tc-99m MAA (microaggregated albulin)
- Tc-99m microaggregated albulin (MAA)
- Tc-99m microaggregated albulin
Tc-99m MAA (macroaggregated albumin) is one of the technetium radiopharmaceuticals used in lung perfusion imaging.
Characteristics
photon energy: 140 KeV
physical half life: 6 hours
biological half life: 2-3 hours
normal distribution: lungs, liver, spleen, kidneys
-
pharmacokinetics:
>90% particles trapped in lung capillaries during first pass
particles <10 μg phagocytosed by liver and spleen
~100,000 of 280 billion capillaries occluded during normal lung perfusion scan (= 0.00003% capillaries occluded)
particles eventually enter systemic circulation and are phagocytosed by the reticuloendothelial system (RES)
excretion: renal, RES
particle size: 5-100 μm
critical organ: lung
Uses, doses and timings
-
V/Q perfusion
adult dose: 74-185 MBq (2-5 mCi) IV (37 MBq (1 mCi) if before ventilation)
timing: immediate
-
reduced injection of 100,000-200,000 particles advised in:
pulmonary hypertension, R-L shunt, single lung transplantation
pregnant patients
pediatric patients: weight-related dosing advised
blood should not be drawn back into the syringe to ensure needle is in vein before injection (in contrast, to other studies). Blood causes MAA aggregation which results in hot pulmonary microemboli
brain uptake is diagnostic of R-L shunt
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