Tc-99m MAG3

Dr Jeremy Jones et al.

Tc-99m MAG3 (mercaptoacetyltriglycine) is one of the technetium radiopharmaceuticals used in renal imaging.


  • photon energy: 140 KeV
  • physical half life: 6 hours
  • biological half life: 4 hours
  • normal distribution: kidneys (100%)
  • pharmacokinetics:
    • uptake by tubular secretion (97%)
    • first pass filtration 60%
  • excretion: renal via both glomeruli infiltration and tubular excretion; hence, in paediatric patients and patients with poor renal function this test is considered superior to DTPA scan
  • target organ: bladder
  • miscellaneous facts
    • good quality images with renal insufficiency
    • by giving captopril, MAG3 plasma clearance decreases in hypertensive patients with renal artery stenosis but increases in patients without renal artery stenosis
    • cannot measure GFR as it is cleared almost entirely by tubular secretion

Uses, doses and timings

  • renal study
    • adult dose: 8 mCi IV
    • paediatric dose: 0.10 mCi/kg (minimum: 0.4 mCi) 5
    • 60 sec flow study; then q5min for 25 min
Physics and imaging technology: nuclear medicine
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Article information

rID: 15558
System: Urogenital
Section: Physics
Synonyms or Alternate Spellings:
  • Technetium-99m mercaptoacetyltriglycine (MAG3)
  • Technicium-99m MAG3
  • Technetium-99m mercaptoacetyltriglycine
  • MAG3

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Cases and figures

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    Right PUJ obstruc...
    Case 1: pelviureteric junction (PUJ) obstruction
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    Case 2: normal
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