Technetium 99m-methyl diphosphonate
Last revised by Mostafa Elfeky on 6 Jan 2022
Citation, DOI, disclosures and article data
Citation:
Venkatesh M, Elfeky M, Bell D, et al. Technetium 99m-methyl diphosphonate. Reference article, Radiopaedia.org (Accessed on 03 Oct 2024) https://doi.org/10.53347/rID-25398
Permalink:
rID:
25398
Article created:
23 Oct 2013,
Manchikanti Venkatesh
Disclosures:
At the time the article was created Manchikanti Venkatesh had no recorded disclosures.
View Manchikanti Venkatesh's current disclosures
Last revised:
6 Jan 2022,
Mostafa Elfeky ◉
Disclosures:
At the time the article was last revised Mostafa Elfeky had no recorded disclosures.
View Mostafa Elfeky's current disclosures
Revisions:
11 times, by
8 contributors -
see full revision history and disclosures
Systems:
Sections:
Synonyms:
- Tc 99m MDP
- 99m-Tc MDP
- 99mTc MDP
- Tc-99m MDP
Technetium 99m-methyl diphosphonate (99mTc MDP) is a radiotracer used in nuclear medicine especially for bone scintigraphy. Any disease process which results in extracellular fluid expansion will lead to accumulation of this tracer.
Radionuclide profile
- photon energy: 140 keV
- physical half-life: 6 hours
- critical organ: urinary bladder
Uses
- osteomyelitis
- fractures, including stress and insufficiency fractures
- malignancy, e.g. osteoid osteoma, bone metastases, soft tissue sarcomas
- painful scoliosis
- post-traumatic hematomas, myositis ossificans, heterotopic ossification
- tumoral calcinosis
- metastatic pulmonary calcification
- sickle cell disease
Quiz questions
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References
- 1. Peller PJ, Ho VB, Kransdorf MJ. Extraosseous Tc-99m MDP uptake: a pathophysiologic approach. Radiographics. 1993;13 (4): 715-34. Pubmed citation
- 2. Adams BK, Parkar S, Al-Haider ZY. Technetium-99m MDP bone scintigraphy shows multiple abnormalities in sickle cell disease. Arch. Dis. Child. 2003;88 (7): 631. Free text at pubmed - Pubmed citation
- 3. Kattan KR, King AY. Presacral space revisited. AJR Am J Roentgenol. 1979;132 (3): 437-9. doi:10.2214/ajr.132.3.437 - Pubmed citation
- 4. Chopra A. 99mTc-Methyl diphosphonate. 2007 Mar 29 [Updated 2009 Aug 24]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013. Available from: http://www.ncbi.nlm.nih.gov/books/NBK24575/
- 5. Weissleder R, Wittenberg J, Harisinghani MMGH et-al. Primer of Diagnostic Imaging. Mosby. (2011) ISBN:0323065384. Read it at Google Books - Find it at Amazon
Incoming Links
Articles:
Cases:
- Hot kidneys (bone scan)
- Ewing sarcoma (bone scan)
- Hyperostosis frontalis interna (bone scan)
- Soft tissue uptake on bone scan - muscle tear
- Erosive arthritis of the manubriosternal joint
- Primary myelofibrosis
- Progressive metastatic prostate cancer
- First metatarsophalangeal joint prosthesis loosening without infection
- Osteoblastic skull metastasis invading the brain
- Langerhans cell histiocytosis (LCH)
- Osteopetrosis
Multiple choice questions:
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