Terminal zones of myelination
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At the time the article was created Ahmed Abdrabou had no recorded disclosures.View Ahmed Abdrabou's current disclosures
At the time the article was last revised Daniel J Bell had no recorded disclosures.View Daniel J Bell's current disclosures
The terminal zones of myelination are located at the posterior aspect of the lateral ventricles (the peritrigonal regions) and are the only part of the cerebral white matter that may exhibit high T2 signal in a normal brain at 2 years of age, when myelination of cerebral white matter normally becomes complete.
- T1 IR: low signal; better sensitivity than conventional T1 sequence
- T2: patches of high signal
Differentiation between these lesions and periventricular leukomalacia (PVL) is important as the terminal zone has no clinical relevance. Detection of normally myelinated low T2 signal white matter in-between the high signal patches and the lateral ventricle favors the diagnosis of terminal zone.
- 1. Barkovich AJ, Kjos BO, Jackson DE et-al. Normal maturation of the neonatal and infant brain: MR imaging at 1.5 T. Radiology. 1988;166 (1 Pt 1): 173-80. Pubmed citation
- 2. Knaap MS, Valk J, Barkhof F. Magnetic resonance of myelination and myelin disorders. Springer Verlag. (2005) ISBN:3540222863. Read it at Google Books - Find it at Amazon
- 3. Osborn A, Blaser S, Salzman K. Encyclopedia of Diagnostic Imaging. AMIRSYS. (2008) ISBN:0721629059. Read it at Google Books - Find it at Amazon