Thallium-201 chloride

Dr Daniel J Bell ◉ and Dr Neil Lall et al.

Thallium-201 chloride is a radiopharmaceutical used primarily in cardiac imaging.

Characteristics

photon energy: 80 keV
physical half life: 73 hours
biological half life
- rest: 3 minutes
- exercise: 30 seconds
normal distribution: myocardium, skeletal muscle, GI tract, liver, kidneys
excretion: renal
target organ: kidneys
pharmacokinetics:
miscellaneous facts:
- more background noise than MUGA
- ²⁰¹Tl-cerebral SPECT can be used to differentiate toxoplasmosis vs lymphoma (increased uptake in lymphoma, decreased in toxoplasmosis)

Uses, doses and timings

Cardiac Scan

adult dose: 55.5 MBq (1.5 mCi) IV

References

Physics and imaging technology: nuclear medicine

radioactivity
- atomic structure
- isotopes
- radioactive decay
  - alpha decay
  - beta decay
  - electron capture decay
  - gamma decay
  - half life
  - decay activity
detectors
- scintillation detectors (gamma camera)
- emission tomography
  - single photon emission computed tomography (SPECT)
  - positron emission tomography (PET)
radiopharmaceuticals
- fundamentals of radiopharmaceuticals
- radiopharmaceutical labeling
- radiopharmaceutical production
  - nuclear reactor produced radionuclides
  - cyclotron produced radionuclides
- radiation detection
  - dosimetry
- specific agents
  - carbon-11
  - chromium-51
  - fluorine-18 FDG
  - gallium agents
    - Ga-67 citrate
    - Ga-68
  - iodine agents
    - I-123
      - I-123 iodide
      - I-123 ioflupane (DaTSCAN)
      - I-123 ortho-iodohippurate
    - I-131
    - MIBG scans
      - I-123 MIBG
      - I-131 MIBG
  - indium agents
    - In-111 Octreoscan
    - In-111 OncoScint
    - In-111 Prostascint
    - In-111 oxine labeled WBC
  - krypton-81m
  - nitrogen-13
  - oxygen-15
  - phosphorus-32
  - selenium-75
    - SeHCAT
  - technetium agents
    - technetium-99m DMSA
    - technetium-99m DTPA
    - technetium-99m DTPA aerosol
    - technetium-99m HMPAO
    - technetium-99m HMPAO labeled WBC
    - technetium-99m MAA
    - technetium-99m MAG3
    - technetium-99m MDP
    - technetium-99m mercaptoacetyltriglycine
    - technetium-99m pertechnetate
    - technetium-99m labeled RBC
    - technetium-99m sestamibi
    - technetium-99m sulfur colloid
    - technetium-99m sulfur colloid (oral)
  - thallium-201 chloride
  - xenon-127
  - xenon-133
- in vivo therapeutic agents
pharmaceuticals used in nuclear medicine

Article information

rID: 24811

System: Central Nervous System, Cardiac

Section: Imaging Technology

Tag: refs, radiopharmaceutical, nucmed

Synonyms or Alternate Spellings:

Tl 201 chloride
Thallous chloride

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