Theranostics (or theragnostics 6) uses a diagnostic examination to determine if a patient may benefit from a specific therapeutic drug and thus couples the therapy with diagnostic information specific for the intended target 2.

Theranostics promises improved patient selection for therapy on the basis of specific molecular features of disease, using information from pharmacogenetics, proteomics, and biomarker profiling to provide a cost-effective targeted management protocol thereby generating a custom-made treatment plan based on the uniqueness of every individual 3.

Selection of patients for any radionuclide therapy is achieved by the demonstration of adequate uptake in all involved tumor sites in order to deliver a radiation absorbed dose sufficient to accomplish therapeutic goals of symptom or disease control.4

History and etymology

The term “theranostic” was coined in 2002 by John Funkhouser 1 and is a portmanteau of the two terms - therapeutics and diagnostics. 

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