Therapy-related myeloid leukaemias, also referred to as therapy-related myeloid neoplasms, occur as a late complication after cytotoxic therapies (e.g. chemotherapy, immunosuppressive therapy, and radiation therapy) performed to treat other conditions. They represent hematological malignancies where a causal relationship has been implied, and have been recognized as distinct entities by the WHO classification of tumors of hematopoietic and lymphoid tissues.
They include:
- therapy-related acute myeloid leukemia (t-AML)
- therapy-related myelodysplastic syndrome (t-MDS)
- therapy-related myelodysplastic syndrome/myeloproliferative neoplasms (t-MDS/MPN)
They are known to have poor outcomes compared to the de novo cases of these entities. For further discussion, please refer to the main articles of each myeloid neoplasm.
Unable to process the form. Check for errors and try again.