Thoracic aortic aneurysms are relatively uncommon compared to abdominal aortic aneurysms. There is a wide range of causes, and the ascending aorta is the segment most commonly affected. Both CTA and MRA are the modalities of choice to image this condition.
The normal aortic diameter varies based on age, sex, and body surface area. In general, the term aneurysm is used when the axial diameter is >5.0 cm for the ascending aorta and >4.0 cm for the descending aorta 12. When enlarged above normal but not reaching aneurysmal definition, the terms dilatation/ectasia can be used 9,12.
Most commonly occur in 50 to 60-year-old age group and incidence is estimated at ~7.5 per 100,000 patient-years 8. There is a male predominance (M:F=3:1).
Thoracic aneurysms are often identified incidentally on imaging of the chest. The symptomatic presentation may be due to mass effect on airway or esophagus. Alternatively, they may present due to a complication, including rupture, aorto-bronchial or aorto-esophageal fistulae.
Pseudoaneurysms of the thoracic aorta are usually the result of significant thoracic trauma, both penetrating and blunt, and carry a very high mortality, with 80-90% of patients dying before reaching hospital 4.
Aneurysmal dilatation can affect any part of the thoracic aorta. Relative frequencies are (with some involving more than one segment) 7:
- aortic root/ascending aorta: 60%
- aortic arch: 10% - aortic arch aneurysms
- descending aorta: 40%
- thoracoabdominal segment: 10%
Thoracic aortic aneurysms can be divided pathologically according to their relationship to the aortic wall 1:
- atherosclerotic aneurysms (most common)
- connective tissue disease
- bicuspid aortic valve
- ciprofloxacin use (maybe quinolone class effect) 13
- quinolones promote loss of extracellular structural integrity, by several non-antimicrobial mechanisms 13
- in the UK, caution is now advised in using quinolones in high-risk patients 14
- mycotic aneurysms
- intracranial cerebral aneurysms (~10% prevalence) 11
The location and shape of thoracic aortic aneurysms are variable. An aortic aneurysm, as aneurysms elsewhere, can be described as saccular or fusiform. In the case of fusiform dilatation, the term aneurysm should be applied when the diameter is >4 cm 1.
The thoracic aorta can usually be seen on both frontal and lateral chest radiographs, and aneurysms are often obvious. However, it is difficult to assess size accurately (due to magnification effects and often poor visualization on the side of the artery).
Additionally, mediastinal masses may mimic aortic aneurysms.
Unlike abdominal aneurysms that can usually be readily assessed and monitored with ultrasound, thoracic aortic aneurysms are encased in bone and air making transthoracic ultrasound of no use.
Transesophageal echocardiography can visualize much of the descending aorta, but due to its invasive nature is not routinely used.
CTA is the work-horse of aneurysm assessment able to rapidly image the relevant vascular territory with high resolution. It can visualize both the sac and the lumen and detect potential complications.
Typically aneurysms appear as dilatations of the lumen. The walls may be thin or thickened by the presence of a mural thrombus (circumferential or more frequently eccentric).
Calcified atherosclerotic disease is often identified not only in the wall of an aneurysm but adjacent arteries.
If rupture or leak has occurred hematoma/fluid may be seen adjacent to the aorta, in the left pleural cavity or the pericardium 1.
See main article: reporting tips for aortic aneurysms.
Although angiography has long been considered the gold standard for vascular imaging, it has largely been superseded by CTA and MRA, which can obtain 3D volumetric data, and able to assess the extraluminal soft tissues.
Angiography is however used during endovascular repair.
MRI has the advantage of not requiring ionizing radiation or large volumes of iodinated contrast 2. This is particularly advantageous in young patients with connective tissue disorders. However, there are limitations in patients with pacemakers and those with reduced renal function (see nephrogenic systemic fibrosis).
Acquisitions capable of being reformatted in three dimensions are essential to allow for accurate luminal measurement 2.
Treatment and prognosis
Mild to moderate aneurysmal dilatation can usually be treated conservatively and monitored. When the diameter reaches 5-6 cm intervention is usually considered as the risk of rupture is significantly elevated 1. Treatment options include:
In general, when possible, endovascular repair is the treatment of choice, with reduced morbidity and mortality 2.
The majority of patients with thoracic aortic aneurysms either die of a direct complication of the aneurysm (rupture most frequently) or other cardiovascular complications 3. The main predictors of rupture are the size and speed of growth 3. The average growth of a thoracic aneurysm appears to be lower than that of abdominal aneurysms, typically in the order of 1-2 mm/year, and correlates with a better prognosis for thoracic aneurysms when controlled for size 3.
- 1. Collins J, Stern EJ. Chest radiology, the essentials. Lippincott Williams & Wilkins. (2007) ISBN:0781763142. Read it at Google Books - Find it at Amazon
- 2. Atar E, Belenky A, Hadad M et-al. MR angiography for abdominal and thoracic aortic aneurysms: assessment before endovascular repair in patients with impaired renal function. AJR Am J Roentgenol. 2006;186 (2): 386-93. doi:10.2214/AJR.04.0449 - Pubmed citation
- 3. Masuda Y, Takanashi K, Takasu J et-al. Expansion rate of thoracic aortic aneurysms and influencing factors. Chest. 1992;102 (2): 461-6. doi:10.1378/chest.102.2.461 - Pubmed citation
- 4. Kato N, Dake MD, Miller DC et-al. Traumatic thoracic aortic aneurysm: treatment with endovascular stent-grafts. Radiology. 1997;205 (3): 657-62. Radiology (abstract) - Pubmed citation
- 5. Reeder MM, Felson B. Reeder and Felson's gamuts in radiology, comprehensive lists of roentgen differential diagnosis. Springer Verlag. (2003) ISBN:0387955887. Read it at Google Books - Find it at Amazon
- 6. Agarwal P, Chughtai A, Matzinger F et-al. Multidetector CT of Thoracic Aortic Aneurysms1. Radiographics. 2009;29 (2): 537-552. Radiographics (full text) - doi:10.1148/rg.292075080
- 7. Isselbacher EM. Thoracic and abdominal aortic aneurysms. Circulation. 2005;111 (6): 816-28. Circulation (full text) - doi:10.1161/01.CIR.0000154569.08857.7A - Pubmed citation
- 8. Lavall D, Schäfers HJ, Böhm M et-al. Aneurysms of the ascending aorta. Dtsch Arztebl Int. 2012;109 (13): 227-33. doi:10.3238/arztebl.2012.0227 - Free text at pubmed - Pubmed citation
- 9. Webb WR, Higgins CB. Thoracic Imaging. Lippincott Williams & Wilkins. (2010) ISBN:1605479764. Read it at Google Books - Find it at Amazon
- 10. Loeys BL, Dietz HC. Loeys-Dietz Syndrome. 2008 Feb 28 [Updated 2013 Jul 11]. In: Pagon RA, Adam MP, Ardinger HH, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2016. Available from: http://www.ncbi.nlm.nih.gov/books/NBK1133/
- 11. Rouchaud A, Brandt MD, Rydberg AM et-al. Prevalence of Intracranial Aneurysms in Patients with Aortic Aneurysms. AJNR Am J Neuroradiol. doi:10.3174/ajnr.A4827 - Pubmed citation
- 12. Munden RF, Carter BW, Chiles C, MacMahon H, Black WC, Ko JP, McAdams HP, Rossi SE, Leung AN, Boiselle PM, Kent MS, Brown K, Dyer DS, Hartman TE, Goodman EM, Naidich DP, Kazerooni EA, Berland LL, Pandharipande PV. Managing Incidental Findings on Thoracic CT: Mediastinal and Cardiovascular Findings. A White Paper of the ACR Incidental Findings Committee. (2018) Journal of the American College of Radiology : JACR. doi:10.1016/j.jacr.2018.04.029 - Pubmed
- 13. Pasternak B, Inghammar M, Svanström H. Fluoroquinolone use and risk of aortic aneurysm and dissection: nationwide cohort study. (2018) BMJ (Clinical research ed.). 360: k678. doi:10.1136/bmj.k678 - Pubmed
- 14. GOV.UK. (2018). Systemic and inhaled fluoroquinolones: small increased risk of aortic aneurysm and dissection; advice for prescribing in high-risk patients. [online] Available at: https://www.gov.uk/drug-safety-update/systemic-and-inhaled-fluoroquinolones-small-increased-risk-of-aortic-aneurysm-and-dissection-advice-for-prescribing-in-high-risk-patients [Accessed 22 Jun. 2019].
- 15. Heuts S, Adriaans BP, Rylski B, Mihl C, Bekkers SCAM, Olsthoorn JR, Natour E, Bouman H, Berezowski M, Kosiorowska K, Crijns HJGM, Maessen JG, Wildberger J, Schalla S, Sardari Nia P. Evaluating the diagnostic accuracy of maximal aortic diameter, length and volume for prediction of aortic dissection. (2020) Heart (British Cardiac Society). 106 (12): 892-897. doi:10.1136/heartjnl-2019-316251 - Pubmed
Related Radiopaedia articles
- acute aortic syndrome
- thoracic aortic aneurysm
- abdominal aortic aneurysm
- endovascular aneurysm repair (EVAR)
- reporting tips for aortic aneurysms
- aortic coarctation
- aortic pseudocoarctation
- cervical aortic arch
- interrupted aortic arch
- transposition of the great arteries
- variant anatomy of the aortic arch
- traumatic aortic injury