Thorotrast is a suspension of radioactive thorium dioxide first produced in Germany in 1928 and used as a contrast agent until the 1950s. Its principal use was for cerebral angiography: 90% of the estimated 50,000-100,000 patients treated received it for this purpose. Umbrathor was another thorium dioxide-based contrast medium which was principally used for assessment of the GI tract.
Thorotrast was an alpha emitter, which was retained by the body, a combination which make it highly carcinogenic. The deposition of Thorotrast was dependent on its radiological use, preparation method, and the age of the preparation. The primary site of deposition was the reticuloendothelial system including the liver, spleen, bone marrow, and lymph nodes.
Hepatic angiosarcoma is the classic Thorotrast-related neoplasm. Other associated cancers include:
- 1. Bohatirchuk FP, Jeletzky TF, Ivan LP. Contact historadiography of nervous tissue impregnated with thorotrast. Am J Roentgenol Radium Ther Nucl Med. 1973;118 (4): 923-6. - Pubmed citation
- 2. Tondreau RL. The retrospectoscope. Egas Moniz 1874-1955. (1985) Radiographics : a review publication of the Radiological Society of North America, Inc. 5 (6): 994-7. doi:10.1148/radiographics.5.6.3916824 - Pubmed
- 3. Stover BJ. Effects of Thorotrast in humans. Health Phys. 1983;44 Suppl 1 : 253-7. - Pubmed citation
- 4. Weber E, Laarbaui F, Michel L et-al. Abdominal pain: do not forget Thorotrast!. Postgrad Med J. 1995;71 (836): 367-8. doi:10.1136/pgmj.71.836.367 - Free text at pubmed - Pubmed citation