Thyroid inferno

Last revised by Mostafa Elfeky on 9 Nov 2023

Thyroid inferno refers to the colour Doppler appearance of the thyroid gland in active Graves disease (inclusive of variants such as Marine-Lenhart syndrome) and consists of multiple small areas of colour flow seen diffusely throughout the gland representing increased vascularity and arteriovenous shunting.

Terminology

Thyroid inferno should not be confused with a thyroid storm (a.k.a. hyperthyroid crisis) which refers to an extreme thyrotoxic clinical presentation.

Differential diagnosis

It should be kept in mind that usually in cases of Hashimoto thyroiditis colour Doppler study shows normal or decreased flow but occasionally there might be hypervascularity similar to a thyroid inferno 1. The hypervascularity in Hashimoto thyroiditis does not reflect thyrotoxicosis. Increased colour Doppler also appears to be common in hypothyroid patients 2,3.

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