Thyroid transcription factor 1 (TTF1) refers to a homeodomain-containing nuclear transcription factor which belongs to the Nkx2 gene family encoded by a gene located on chromosome 14q13.
It is expressed in the forebrain, thyroid and lung tissues. The presence of TTF-1 protein on a tissue sample is useful in the diagnosis of lung cancer and can be expressed in up to 90% of pulmonary small cell carcinoma but usually not in squamous cell carcinoma.
It is rarely expressed in some primary extrapulmonary tumors 1.
Some publications suggest its "overexpression" may result a more favorable overall prognosis 4.
- 1. Verset L, Arvanitakis M, Loi P, Closset J, Delhaye M, Remmelink M, Demetter P. TTF-1 positive small cell cancers: Don't think they're always primary pulmonary!. (2011) World journal of gastrointestinal oncology. 3 (10): 144-7. doi:10.4251/wjgo.v3.i10.144 - Pubmed
- 2. Ordóñez NG. Thyroid transcription factor-1 is not expressed in squamous cell carcinomas of the lung: an immunohistochemical study with review of the literature. (2012) Applied immunohistochemistry & molecular morphology : AIMM. 20 (6): 525-30. doi:10.1097/PAI.0b013e318251d8c1 - Pubmed
- 3. Camilleri-Broet S, Alifano M, Morcos M, Comperat E, Magdeleinat P, Marmey B, Molina TJ, Régnard JF, Audouin J. Peroperative frozen section analysis of TTF-1 antigen expression. (2004) Journal of clinical pathology. 57 (1): 98-100. doi:10.1136/jcp.57.1.98 - Pubmed
- 4. Qian HH, Xu TS, Cai XQ, Ji TL, Guo HX. Prognostic value of TTF-1 expression in patients with non-small cell lung cancer: A meta-analysis. (2015) Clinica chimica acta; international journal of clinical chemistry. 451 (Pt B): 208-14. doi:10.1016/j.cca.2015.01.023 - Pubmed