Citation, DOI & article data
Time-to-Maximum (Tmax) is a perfusion parameter used both in CT perfusion and MRI perfusion and reflects the time delay between the contrast bolus arriving in the proximal large vessel arterial circulation (arterial input function) and the brain parenchyma 1. It is calculated by deconvoluting the arterial input function 1.
Although Tmax is widely used in defining tissue at risk of infarction in the setting of ischemic stroke it is susceptible to a variety of distortions particularly in the setting of inflow vascular abnormalities 1,2.
- 1. Wouters A, Christensen S, Straka M, Mlynash M, Liggins J, Bammer R, Thijs V, Lemmens R, Albers GW, Lansberg MG. A Comparison of Relative Time to Peak and Tmax for Mismatch-Based Patient Selection. (2017) Frontiers in neurology. 8: 539. doi:10.3389/fneur.2017.00539 - Pubmed
- 2. Fernando Calamante, Søren Christensen, Patricia M. Desmond, Leif Østergaard, Stephen M. Davis, Alan Connelly. The Physiological Significance of the Time-to-Maximum (Tmax) Parameter in Perfusion MRI. (2010) Stroke. 41 (6): 1169-74. doi:10.1161/STROKEAHA.110.580670 - Pubmed