Tophi (plural of tophus) usually appear as lumps on the skin over affected joints due to deposits of monosodium urate crystals in patients with longstanding high levels of serum uric acid (hyperuricemia). Tophi are a pathognomonic feature of gout.
History and etymology
Tophus means "stone" in Latin.
- 1. Fauci AS. Harrison's principles of internal medicine. New York: McGraw-Hill, Medical Publishing Division; 2008.