TP53

The TP53 gene, located on chromosome 17, is a tumour suppressor gene, responsible for the production of the p53 protein, a transcription regulatory protein which works in concert with a number of other proteins, together forming the p53 pathway 1,2.

Inherited mutations in this gene result in the rare hereditary cancer condition known as Li-Fraumeni syndrome, which predisposes to a wide variety of malignancies 1

Somatic mutations are, however, very common within many malignancies. 

Share article

Article information

rID: 53510
Synonyms or Alternate Spellings:
  • p53
  • p53 protein
  • TP53 gene
  • p53 pathway

Support Radiopaedia and see fewer ads

Updating… Please wait.
Loadinganimation

Alert accept

Error Unable to process the form. Check for errors and try again.

Alert accept Thank you for updating your details.