TP53 (gene)
Last revised by Yuranga Weerakkody on 25 Oct 2023
Citation, DOI, disclosures and article data
Citation:
Gaillard F, Weerakkody Y, Bell D, et al. TP53 (gene). Reference article, Radiopaedia.org (Accessed on 18 Apr 2024) https://doi.org/10.53347/rID-53510
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rID:
53510
Article created:
Disclosures:
At the time the article was created Frank Gaillard had no recorded disclosures.
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Last revised:
25 Oct 2023,
Yuranga Weerakkody ◉
Disclosures:
At the time the article was last revised Yuranga Weerakkody had no financial relationships to ineligible companies to disclose.
View Yuranga Weerakkody's current disclosures
Revisions:
5 times, by
4 contributors -
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Systems:
Sections:
Synonyms:
- p53
- p53 protein
- TP53 gene
- p53 pathway
The TP53 gene, located on chromosome 17, is a tumor suppressor gene, responsible for the production of the p53 protein, a transcription regulatory protein which works in concert with a number of other proteins, together forming the p53 pathway 1,2.
Inherited mutations in this gene result in the rare hereditary cancer condition known as Li-Fraumeni syndrome, which predisposes to a wide variety of malignancies 1.
Somatic mutations are, however, very common within many malignancies.
References
- 1. Waun Ki Hong, William N. Hait. Holland Frei Cancer Medicine Eight. ISBN: 9781607950141
- 2. Surget S, Khoury MP, Bourdon JC. Uncovering the role of p53 splice variants in human malignancy: a clinical perspective. OncoTargets and therapy. 7: 57-68. doi:10.2147/OTT.S53876 - Pubmed
- 3. Rivlin N, Brosh R, Oren M, Rotter V. Mutations in the P53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis. Genes Cancer. 2011;2(4):466-74. doi:10.1177/1947601911408889 - Pubmed
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Articles:
- Li-Fraumeni syndrome
- Glioblastoma, IDH-wildtype
- Dysembryoplastic neuroepithelial tumour
- Malignant peripheral nerve sheath tumour
- Pilocytic astrocytoma
- Giant cell glioblastoma
- Medulloblastoma, SHH-activated
- Diffuse midline glioma, H3 K27-altered
- Gliosarcoma
- Head and neck squamous cell carcinomas
- Pancreatic ductal adenocarcinoma
- Aflatoxins
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