TP53 (gene)

Last revised by Yuranga Weerakkody on 25 Oct 2023

Citation, DOI, disclosures and article data

Citation:

Gaillard F, Weerakkody Y, Bell D, et al. TP53 (gene). Reference article, Radiopaedia.org (Accessed on 18 Apr 2024) https://doi.org/10.53347/rID-53510

DOI:

https://doi.org/10.53347/rID-53510

Permalink:

https://radiopaedia.org/articles/53510

rID:

53510

Article created:

22 May 2017, Frank Gaillard ◉ ◈

Disclosures:

At the time the article was created Frank Gaillard had no recorded disclosures.

View Frank Gaillard's current disclosures

Last revised:

25 Oct 2023, Yuranga Weerakkody ◉

Disclosures:

At the time the article was last revised Yuranga Weerakkody had no financial relationships to ineligible companies to disclose.

View Yuranga Weerakkody's current disclosures

Revisions:

5 times, by 4 contributors - see full revision history and disclosures

Systems:

Oncology

Sections:

Pathology

Synonyms:

p53
p53 protein
TP53 gene
p53 pathway

The TP53 gene, located on chromosome 17, is a tumor suppressor gene, responsible for the production of the p53 protein, a transcription regulatory protein which works in concert with a number of other proteins, together forming the p53 pathway ^1,2.

Inherited mutations in this gene result in the rare hereditary cancer condition known as Li-Fraumeni syndrome, which predisposes to a wide variety of malignancies ¹.

Somatic mutations are, however, very common within many malignancies.