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At the time the article was created Frank Gaillard had no recorded disclosures.View Frank Gaillard's current disclosures
At the time the article was last revised Frank Gaillard had no recorded disclosures.View Frank Gaillard's current disclosures
The TP53 gene, located on chromosome 17, is a tumor suppressor gene, responsible for the production of the p53 protein, a transcription regulatory protein which works in concert with a number of other proteins, together forming the p53 pathway 1,2.
Inherited mutations in this gene result in the rare hereditary cancer condition known as Li-Fraumeni syndrome, which predisposes to a wide variety of malignancies 1.
Somatic mutations are, however, very common within many malignancies.
- 1. Waun Ki Hong, William N. Hait. Holland Frei Cancer Medicine Eight. ISBN: 9781607950141
- 2. Surget S, Khoury MP, Bourdon JC. Uncovering the role of p53 splice variants in human malignancy: a clinical perspective. OncoTargets and therapy. 7: 57-68. doi:10.2147/OTT.S53876 - Pubmed