TP53 (gene)

Last revised by Frank Gaillard on 4 Feb 2022

The TP53 gene, located on chromosome 17, is a tumor suppressor gene, responsible for the production of the p53 protein, a transcription regulatory protein which works in concert with a number of other proteins, together forming the p53 pathway 1,2.

Inherited mutations in this gene result in the rare hereditary cancer condition known as Li-Fraumeni syndrome, which predisposes to a wide variety of malignancies 1

Somatic mutations are, however, very common within many malignancies. 

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