Transfusion-related acute lung injury
Citation, DOI, disclosures and article data
At the time the article was created Yuranga Weerakkody had no recorded disclosures.View Yuranga Weerakkody's current disclosures
At the time the article was last revised Yaïr Glick had no financial relationships to ineligible companies to disclose.View Yaïr Glick's current disclosures
Transfusion-related acute lung injury (TRALI) is defined as non-cardiogenic pulmonary edema temporally related to transfusion therapy.
It tends to occur within 6 hours after a blood transfusion and requires exclusion of other alternative diagnoses such as sepsis or volume overload.
On this page:
Shows features of pulmonary edema which can progress to alveolar and interstitial infiltrates. The lung opacities usually clear within 96 hours in 80% of patients.
Treatment and prognosis
It tends to be self-limiting and treatment is supportive, with a prognosis substantially better than most causes of clinical acute lung injury.
- 1. Toy P, Popovsky MA, Abraham E et-al. Transfusion-related acute lung injury: definition and review. Crit. Care Med. 2005;33 (4): 721-6. Crit. Care Med. (link) - Pubmed citation
- 2. Looney MR, Gropper MA, Matthay MA. Transfusion-related acute lung injury: a review. Chest. 2004;126 (1): 249-58. doi:10.1378/chest.126.1.249 - Pubmed citation
- 3.Carcano C, Okafor N, Martinez F, Ramirez J, Kanne J, Kirsch J. Radiographic manifestations of transfusion-related acute lung injury. Clinical imaging. 37 (6): 1020-3. doi:10.1016/j.clinimag.2013.06.008 - Pubmed