Transient abnormal myelopoiesis

Last revised by Rohit Sharma on 25 Apr 2022

Transient abnormal myelopoiesis (TAM) is a phenomenon that can happen in the fetuses or neonates with trisomy 21. The condition can mimic leukemia.


The estimated incidence is at ~10% of newborns with trisomy 21 3.

Radiographic features

Antenatal ultrasound

In the context of known trisomy 21, features that may suggest towards the diagnosis include:

Treatment and prognosis

Although it can closely mimic leukemia, most neonates who survive to 4-8 weeks show complete remission. There is however a very high risk development of acute myeloid leukemia around 2-3 years of age.

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