Transient abnormal myelopoiesis

Transient abnormal myelopoiesis (TAM) is a phenomenon that can happen in the fetuses or neonates with trisomy 21. The condition can mimic leukaemia.


The estimated incidence is at ~10% of newborns with trisomy 21 3.

Radiographic features

Antenatal ultrasound

In the context of known trisomy 21, features that may suggest towards the diagnosis include:

Treatment anf prognosis

Although is can closely mimic leukaemia most neonates who survive 4 to 8 weeks show complete remission. There is however a very high risk development of acute myeloid leukaemia around 2-3 years of age.

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Article information

rID: 15481
Tag: cases
Synonyms or Alternate Spellings:
  • Transient abnormal myelopoiesis (TAM)

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