Citation, DOI, disclosures and article data
Citation:
Radswiki T, Campos A, Sharma R, et al. Transient abnormal myelopoiesis. Reference article, Radiopaedia.org (Accessed on 08 Oct 2024) https://doi.org/10.53347/rID-15481
Transient abnormal myelopoiesis (TAM) is a phenomenon that can happen in the fetuses or neonates with trisomy 21. The condition can mimic leukemia.
Epidemiology
The estimated incidence is at ~10% of newborns with trisomy 21 3.
Radiographic features
Ultrasound
In the context of known trisomy 21, features that may suggest towards the diagnosis include:
Treatment and prognosis
Although it can closely mimic leukemia, most neonates who survive to 4-8 weeks show complete remission. There is however a very high risk development of acute myeloid leukemia around 2-3 years of age.
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2. Leukemia and Lymphoma Reviews, Vol. 1. (1992) ISBN: 371865251X - Google Books
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3. Kim G & Lee E. Prenatal Diagnosis of Transient Abnormal Myelopoiesis in a Down Syndrome Fetus. Korean J Radiol. 2009;10(2):190-3. doi:10.3348/kjr.2009.10.2.190 - Pubmed
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4. Kikuchi A, Tamura N, Ishii K et-al. Four cases of fetal hypoechoic hepatomegaly associated with Trisomy 21 and transient abnormal myelopoiesis. Prenat. Diagn. 2007;27 (7): 665-9. doi:10.1002/pd.1738 - Pubmed citation
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5. Hamada H, Yamada N, Watanabe H et-al. Hypoechoic hepatomegaly associated with transient abnormal myelopoiesis provides clues to trisomy 21 in the third-trimester fetus. Ultrasound Obstet Gynecol. 2001;17 (5): 442-4. doi:10.1046/j.1469-0705.2001.00362.x - Pubmed citation
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