Citation, DOI, disclosures and article data
Citation:
Di Muzio B, Knipe H, Bell D, Transient arterial phase respiratory motion-related artifact. Reference article, Radiopaedia.org (Accessed on 18 Apr 2024) https://doi.org/10.53347/rID-76869
Disclosures:
At the time the article was last revised Henry Knipe had the following disclosures:
- Integral Diagnostics, Shareholder (ongoing)
- Micro-X Ltd, Shareholder (ongoing)
These were assessed during peer review and were determined to
not be relevant to the changes that were made.
View Henry Knipe's current disclosures
Transient arterial phase respiratory motion-related artifact refers to common self-limited dyspnea observed immediately after administering gadoxetate disodium during liver MRI studies. Awareness about this potential artefact when choosing this hepatospecific contrast agent (Primovist/Eovist) is vital, as the motion degradation of the images can result in a non-diagnostic MRI.
The pathophysiology behind this phenomenon is poorly understood and its incidence is reported at ~10% (range 2.4-18%) 1-4.
Although described with other gadolinium agents 5, this self-limited dyspnea is much more prevalent with gadoxetate disodium. Risk factors include prior episodes, high-volume gadoxetate, low body weight, history of iodinated contrast media allergy, chronic obstructive pulmonary disease (COPD), supplemental oxygen, and modified breath-holding 5.
A few techniques have been proposed to overcome this artifact 5:
slower injection rate at 1 mL/sec
increased gadoxetate dose
subtraction imaging may increase the sensitivity of arterial phase enhancement
multiple arterial phase acquisitions
-
1. Kim S, Park S, Wu E et al. Transient Respiratory Motion Artifact During Arterial Phase MRI with Gadoxetate Disodium: Risk Factor Analyses. AJR Am J Roentgenol. 2015;204(6):1220-7. doi:10.2214/AJR.14.13677 - Pubmed
-
2. Davenport M, Viglianti B, Al-Hawary M et al. Comparison of Acute Transient Dyspnea After Intravenous Administration of Gadoxetate Disodium and Gadobenate Dimeglumine: Effect on Arterial Phase Image Quality. Radiology. 2013;266(2):452-61. doi:10.1148/radiol.12120826 - Pubmed
-
3. Ringe K, von Falck C, Raatschen H, Wacker F, Hinrichs J. Evaluation of Transient Respiratory Motion Artifact at Gadoxetate Disodium-Enhanced MRI-Influence of Different Contrast Agent Application Protocols. PLoS One. 2018;13(7):e0200887. doi:10.1371/journal.pone.0200887 - Pubmed
-
4. Shah M, Flusberg M, Paroder V, Rozenblit A, Chernyak V. Transient Arterial Phase Respiratory Motion-Related Artifact in MR Imaging of the Liver: An Analysis of Four Different Gadolinium-Based Contrast Agents. Clin Imaging. 2017;41:23-7. doi:10.1016/j.clinimag.2016.09.004 - Pubmed
-
5. Tan C, Chou S, Inmutto N et al. Gadoxetate-Enhanced MRI as a Diagnostic Tool in the Management of Hepatocellular Carcinoma: Report from a 2020 Asia-Pacific Multidisciplinary Expert Meeting. Korean J Radiol. 2022;23(7):697. doi:10.3348/kjr.2021.0593 - Pubmed
Promoted articles (advertising)
Unable to process the form. Check for errors and try again.