Transient global amnesia (TGA) is a clinical syndrome with no clear etiology identified. Most symptoms are transient and resolve within a few hours.
Most common in patients of older age (50-70 years old).
Anterograde and partial retrograde amnesia lasting less than 24 hours without any other neurological or congestive symptoms. Most cases show complete resolution of symptoms within a few hours from onset of symptoms.
Several hypotheses (e.g. epileptic phenomena, stroke, focal ischemia) have been proposed with no consensus on the exact mechanism 1.
Brain CT scan and conventional sequences of MRI brain show no abnormalities.
Prospective and retrospective studies based on a small number of TGA patients can detect small punctate regions of abnormally restricted diffusion on DWI/ADC sequences in the CA1 area of the hippocampus (lateral edge of the hippocampal gyrus abutting the temporal horn). These lesions can be bilateral and even multifocal 2-4.
Treatment and prognosis
No treatment is required and the condition tends to not recur 5.
- 1. Markowitsch HJ, Staniloiu A. Amnesic disorders. 2012;doi:10.1016/S0140-6736(11)61304-4 - Pubmed citation
- 2. Choi BS, Kim JH, Jung C et-al. High-Resolution Diffusion-Weighted Imaging Increases Lesion Detectability in Patients with Transient Global Amnesia. 2012;doi:10.3174/ajnr.A3072 - Pubmed citation
- 3. Weon YC, Kim JH, Lee JS et-al. Optimal diffusion-weighted imaging protocol for lesion detection in transient global amnesia. AJNR Am J Neuroradiol. 2008;29 (7): 1324-8. doi:10.3174/ajnr.A1105 - Pubmed citation
- 4. Enzinger C, Thimary F, Kapeller P et-al. Transient global amnesia: diffusion-weighted imaging lesions and cerebrovascular disease. Stroke. 2008;39 (8): 2219-25. doi:10.1161/STROKEAHA.107.508655 - Pubmed citation
- 5. Quinette P, Guillery-Girard B, Dayan J, de la Sayette V, Marquis S, Viader F, Desgranges B, Eustache F. What does transient global amnesia really mean? Review of the literature and thorough study of 142 cases. Brain : a journal of neurology. 129 (Pt 7): 1640-58. doi:10.1093/brain/awl105 - Pubmed