Transitional meningioma

Last revised by Daniel J Bell on 18 Mar 2024

Transitional meningiomas are also known as mixed meningiomas because they have components of meningothelial and fibrous subtypes of meningiomas.

Their epidemiology, clinical aspects, radiographic characteristics, treatment, prognosis, and differential diagnosis are in the main article (see meningioma).


The WHO classification guidelines recognize several histopathological subtypes of meningiomas 1-3. The most common histological subtypes are WHO grade I meningothelial, fibrous, and transitional meningiomas 2. Transitional meningiomas demonstrate features of both meningothelial and fibroblastic subtypes 4.

Microscopic appearance

Transitional meningiomas demonstrate meningothelial cells arranged in fascicles of variable length, with the fibroblastic appearance and syncytial pattern, prominent whorling epithelioid cells, and admixed spindle cells 4. There are abundant indistinct cytoplasmic boundaries, with imperceptible cell membranes, benign nuclear features, and occasional intranuclear inclusion bodies 4.

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