Trastuzumab deruxtecan related interstitial lung disease

Last revised by Liz Silverstone on 11 Sep 2024

Trastuzumab deruxtecan related interstitial lung disease (T-Dxd ILD) is a form of drug induced lung disease which can rarely occur with the antibody-drug conjugate trastuzumab deruxtecan (T-DXd). It can cause a fatal pneumonitis and therefore its recognition is important.

Radiographic features

CT

Several patterns of lung injury have been described which include 2:

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