Trigeminal nerve

The trigeminal nerve is the fifth cranial nerve and its primary role is relaying sensory information from the face and head, although it does provide motor control to the muscles of mastication. It is both large and complicated and has multiple brainstem nuclei (sensory and motor) as well as many interconnections with other cranial nerves. It swaps parasympathetic fibers and taste fibers somewhat haphazardly and divides into numerous terminal branches.

Gross anatomy

Nuclei

There are four cranial nerve nuclei:  three sensory and one motor. 

The sensory nuclei are arranged in a column which spans from the midbrain through the pons and medulla and into the upper cervical cord.

  1. mesencephalic nucleus: proprioceptive fibers for muscles of the face, orbit, mastication, and tongue; extends through the whole length of the midbrain, lateral to the cerebral aqueduct  
  2. main sensory nucleus: located in the upper pons, lateral to the motor nucleus, is responsible for touch sensation for all three trigeminal divisions
  3. spinal nucleus: lower pons to upper cervical cord (as far as the third cervical segment), is responsible for pain and temperature; additionally it receives afferent fibers from the glossopharyngeal nerve and vagus nerve.

The motor nucleus is located in the upper pons and gives off the smaller motor root which bypasses the trigeminal ganglion and innervates the muscles of mastication as well as mylohyoid, the anterior belly of digastric, tensor tympani and tensor palatini.

Intracranial component

The trigeminal nerve exits at the mid pons anteriorly, courses through the prepontine cistern (cisternal portion), and crosses the porus trigeminus to enter a prolongation of dura at the apex of the petrous temporal bone known as the Meckel cave (cavernous portion) where its fibers form the trigeminal ganglion, which is also known as the Gasserian or semilunar ganglion. It then divides into three main branches known as divisions:

Ophthalmic division / nerve (V1 or Va)

Courses anteriorly in the lateral wall of the cavernous sinus inferior to the trochlear nerve and is crossed medially by the oculomotor nerve. Just before entering the orbit, the tentorial nerve arises and ascends to supply a large portion of the falx and supratentorial dura. The ophthalmic division then divides into 3 terminal branches before each passes through the superior orbital fissure separately:

Maxillary division / nerve (V2 or Vb)

Courses anteriorly low in the lateral wall of the cavernous sinus inferior to the ophthalmic division. Just before exiting the skull it runs along the floor of the middle cranial fossa and gives off the middle meningeal nerve which ascends to supply the anterior dura of the middle cranial fossa. It then passes through the foramen rotundum in the greater wing of the sphenoid bone to exit the skull and enter the superior aspect of the pterygopalatine fossa. It gives branches to the pterygopalatine ganglion but also receives parasympathetic nerves from the ganglion via the greater petrosal nerve. It then divides into the:

Mandibular division / nerve (V3 or Vc)

Courses inferiorly through the foramen ovale to enter the infratemporal fossa, hence it does not pass through the cavernous sinus. It consists of a sensory root and a smaller motor root, the latter which bypasses the trigeminal ganglion inferiorly. These roots pass through the foramen ovale separately and then unite just below the foramen. It immediately gives off nervus spinosus and nerve to medial pterygoid from the main trunk. It then descends in the infratemporal fossa passing between the tensor veli palatini and lateral pterygoid muscles before dividing into anterior and posterior divisions:

Related pathology

Anatomy: Brain

Anatomy: Brain

Anatomy: Head and neck

Anatomy: Head and neck

Article information

rID: 2207
Section: Anatomy
Synonyms or Alternate Spellings:
  • Trigeminal nerve (CN V)
  • Trigeminal nerve (V)
  • Nervus trigeminus

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Cases and figures

  • Figure 1: trigeminal nerve
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  • Figure 2: CN V and CN VII connections
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  • Figure 3: brainstem nuclei
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  • Figure 4: cranial nerve origins (illustration)
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  • Figure 5: cranial nerves
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  • Figure 6: ophthalmic division
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  • Figure 7: maxillary division
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  • Figure 8: mandibular division
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  • Figure 9: sensation
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  • Figure 10: trigeminal nerve cutaneous distribution (Gray's anatomy)
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  • Figure 11: cranial nerves in the posterior fossa (Gray's illustration)
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  • Figure 12: upper pons - CN V (diagram)
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  • Figure 13: mid pons - CN V (diagram)
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  • Figure 14: lower pons - CN V (diagram)
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  • Figure 15: branch of the ophthalmic division of the trigeminal nerve (Gray's illustration)
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  • Figure 16: nerves of the orbit (Gray's illustration)
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  • Figure 17: maxillary and mandibular divisions of the trigeminal nerve (Gray's illustration)
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  • Figure 18: maxillary division of the trigeminal nerve (Gray's illustration)
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  • Figure 19: pterygopalatine ganglion and nasal nerves
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  • Figure 20: mandibular division of the trigeminal nerve (Gray's illustration)
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  • Figure 21: mandibular division of the trigeminal nerve and submandibular and otic ganglia (Gray's illustration)
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  • Figure 22: nerves of the face, scalp and neck (Gray's illustration)
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  • Figure 23: cranial nerves
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