An abnormal test result doesn't indicate a birth defect, it could be because of a disparity in the estimated gestational age, similarly not all defects can be detected by this test.
Triple screens are most accurate between the 16th and the 18th weeks; however they may be done between 15th and 22nd weeks.
If found abnormal further ultrasound screening and amniocentesis may be suggested.
- 1. Reynolds T. The triple test as a screening technique for Down syndrome: reliability and relevance. Int J Womens Health. 2011;2: 83-8. Free text at pubmed - Pubmed citation
- 2. Tanski S, Rosengren SS, Benn PA. Predictive value of the triple screening test for the phenotype of Down syndrome. Am. J. Med. Genet. 1999;85 (2): 123-6. Pubmed citation