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Tuberculosis

Dr Henry Knipe and Assoc Prof Frank Gaillard et al.

Tuberculosis encompasses an enormously wide disease spectrum affecting multiple organs and body systems predominantly caused by the organism Mycobacterium tuberculosis. A small proportion can also be caused by Mycobacterium bovis

Although tuberculosis continues to be very common in developing nations. Approximately 10 million people globally per year have positive exposure to tuberculosis 6. In Western industrialised populations it has become uncommon but is increasing in prevalence among immunocompromised patients, particularly those with HIV/AIDS. An estimated 5% HIV patients have Mycobacterium tuberculosis infections, which become clinically apparent when CD4+ counts drop to below 350 cells/mm3, typically with findings of post-primary pulmonary tuberculosis 2.

Clinical presentation will depend upon the morphology of infection and location. These are discussed in separate articles. 

Aristotle is usually credited as being the first to recognize the contagious nature of the disease. Discovery of the specific infectious agent, the tubercle bacillus (Mycobacterium tuberculosis), did not occur for several millennia until it was isolated by Robert Koch in 1882 4. M. tuberculosis was previously known as Koch bacillus and tuberculosis known as Koch disease 5. It was also historically known as consumption due to the severe associated weight loss.

Tuberculosis

Article information

rID: 2221
Synonyms or Alternate Spellings:
  • Tuberculosis (overview)
  • TB
  • Tuberculosis: general
  • Koch bacillus
  • Koch disease
  • Koch's disease
  • Koch's bacillus
  • Consumption

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Cases and figures

  • Figure 1: diagram - WHO 2005 tuberculosis prevalence
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  • Case 1: pulmonary tuberculosis
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  • Figure 2: histology
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  • Case 2: scrofula
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  • Figure 3: scrofula - photograph
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  • Case 4: concommitant pulmonary TB and scrofula
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  • Case 5: pulmonary tuberculosis with cavity
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  • Case 6: Pott's disease
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  • Case 7: pulmonary TB with hilar lymphadenopathy
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  • Tuberculous Arthr...
    Case 8: tuberculous arthritis
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  • Case 10: involving foot
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  • Case 11: miliary tuberculosis
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  • Case 12: ileocecal tuberculosis
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  • Case 13: Pulmonary tubrculosis
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  • Case 14: Retroperitoneal tuberculosis resulting in renal obstruction
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  • Case 15: terminal ileal tuberculosis
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  • Case 16: mediastinal lymphadenopathy
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