Tuberculosis

Tuberculosis encompasses an enormously wide disease spectrum affecting multiple organs and body systems predominantly caused by the organism Mycobacterium tuberculosis. A small proportion can also be caused Mycobacterium bovis

Although TB continues to be very common in developing nations, in western industrialised populations it has become uncommon but is increasing in prevalence among immunocompromised patients, particularly those with AIDS. An estimated 5% HIV patients have Mycobacterium tuberculosis infections, which become clinically apparent when CD4+ counts drop to below 350 cells/mm3, typically with findings of post-primary pulmonary tuberculosis 2.

Clinical presentation will depend upon the morphology of infection and location. These are discussed in separate articles. 

Aristotle is usually credited as being the first to recognise the contagious nature of the disease. Discovery of the specific infectious agent, the tubercle bacillus (Mycobacterium tuberculosis), did not occur for several more centuries until it was isolated by Robert Koch in 1882 4. M. tuberculosis was previously known as Koch bacillus and tuberculosis known as Koch disease 5


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Article Information

rID: 2221
System: Chest
Section: Pathology
Synonyms or Alternate Spellings:
  • TB
  • Tuberculosis: general
  • Koch bacillus
  • Koch disease
  • Koch's disease
  • Koch's bacillus

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Cases and Figures

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    Figure 1: diagram - WHO 2005 tuberculosis prevalence
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    Case 1: pulmonary tuberculosis
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    Figure 2: histology
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    Coronal CT
    Case 2: scrofula
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    Figure 3: scrofula - photograph
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    Tuberculosis - ce...
    Case 3: concommitant pulmonary TB and scrofula
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    CT neck, windowed...
    Case 4: concommitant pulmonary TB and scrofula
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    Case 5: pulmonary tuberculosis with cavity
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    Saital T1 post Gad
    Case 6: Pott's disease
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    Case 7: pulmonary TB with hilar lymphadenopathy
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    Tuberculous Arthr...
    Case 8: tuberculous arthritis
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    Case 10: involving foot
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    Case 11: miliary tuberculosis
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    Case 12: ileocaecal tuberculosis
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    Case 13: Pulmonary tubrculosis
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