Tuberculosis encompasses an enormously wide disease spectrum affecting multiple organs and body systems predominantly caused by the organism Mycobacterium tuberculosis. A small proportion can also be caused Mycobacterium bovis.
Although TB continues to be very common in developing nations, in western industrialised populations it has become uncommon but is increasing in prevalence among immunocompromised patients, particularly those with AIDS. An estimated 5% HIV patients have Mycobacterium tuberculosis infections, which become clinically apparent when CD4+ counts drop to below 350 cells/mm3, typically with findings of post-primary pulmonary tuberculosis 2.
Clinical presentation will depend upon the morphology of infection and location. These are discussed in separate articles.
History and etymology
Aristotle is usually credited as being the first to recognise the contagious nature of the disease. Discovery of the specific infectious agent, the tubercle bacillus (Mycobacterium tuberculosis), did not occur for several more centuries until it was isolated by Robert Koch in 1882 4. M. tuberculosis was previously known as Koch bacillus and tuberculosis known as Koch disease 5.
- causative agent
- tuberculoma (tuberculous granuloma)
- tuberculous abscess
- miliary tuberculosis
- pulmonary tuberculosis
- cardiac tuberculosis
- intracranial tuberculosis
- tuberculous otomastoiditis
- gastrointestinal tuberculosis
- genitourinary tuberculosis
- skeletal tuberculosis
- tuberculous mastitis
- tuberculous lymphadenopathy
- tuberculous adrenalitis
- 1. Burrill J, Williams CJ, Bain G et-al. Tuberculosis: a radiologic review. Radiographics. 27 (5): 1255-73. doi:10.1148/rg.275065176 - Pubmed citation
- 2. Kazerooni EA, Gross BH. Cardiopulmonary imaging. Lippincott Williams & Wilkins. (2004) ISBN:0781736552. Read it at Google Books - Find it at Amazon
- 3. Jung YY, Kim JK, Cho KS. Genitourinary tuberculosis: comprehensive cross-sectional imaging. AJR Am J Roentgenol. 2005;184 (1): 143-50. AJR Am J Roentgenol (full text) - Pubmed citation
- 4. Leung AN. Pulmonary tuberculosis: the essentials. Radiology. 1999;210 (2): 307-22. Radiology (full text) - Pubmed citation
- 5. Join AMMA. History of Tuberculosis. Part 2–the Sanatoria and the Discoveries of the Tubercle Bacillus. Journal of Military and Veterans' Health. 2014;22(2). Available from: http://jmvh.org/article/history-of-tuberculosis-part-2-the-sanatoria-and-the-discoveries-of-the-tubercle-bacillus/