Tuberculous peritonitis

Last revised by Joshua Yap on 30 Sep 2022

Tuberculous peritonitis is a form of extrapulmonary tuberculosis affecting the peritoneum. It is frequently seen in association with other forms of gastrointestinal tuberculosis 6.

Tuberculosis is usually confined to the respiratory system but may involve any organ system 1. Extrapulmonary manifestations may affect up to 15% of patients with tuberculosis.

Risk factors for peritoneal involvement include 9:

  • concomitant HIV infection

  • peritoneal dialysis

  • cirrhosis

Reactivation of tuberculous collections lying dormant in the peritoneum accounts for the majority of cases. Direct spread may occur from the gastrointestinal tract, and dissemination through lymphatic or hematogenous means has also been described. Direct extension from the female genital tract has been described 11

Tuberculous peritonitis is commonly classified as follows:

  • wet type

    • most common (~90%) 1

  • dry type

  • fibrotic-fixed type

Of note, there is considerable overlap between the three types.

The abdomen is the most common site of extrapulmonary tuberculosis, with peritoneal disease being the commonest form within the abdomen. Abdominal tuberculosis can also involve the solid organs, gastrointestinal tract, mesentery, and lymph nodes 2.

Tuberculosis in different organ systems may mimic alternate pathology so histopathological or laboratory evidence is often required to support suspicions on imaging before commencing treatment.

CT imaging features seen with tuberculous peritonitis include:

In addition, there can be more specific imaging features seen with individual types:

  • wet type: exudative high attenuation ascites (20-45 HU), which may be free or loculated; high attenuation of the ascites is thought to be due to high protein and cellular content

  • dry type: caseous mesenteric lymphadenopathy and fibrous adhesions; thickened, "cake-like" omentum

  • fibrotic type: omental "cake-like" mass with fixed bowel loops; matted loops and mesentery with loculated ascites

The omental involvement may be "cake-like", nodular, or smudged, but all appearances are similar to peritoneal carcinomatosis, which is the main differential diagnosis.

When the gastrointestinal tract is involved mural thickening of the ileocecal region is the most common site and can occur in conjunction with peritoneal involvement 4.

  • diffuse peritoneal thickening

    • regular and hypoechoic enlargement of the parietal peritoneum is common, and may also demonstrate an irregular/nodular pattern 8

    • often hypervascular with color flow Doppler interrogation

  • ascites 7

    • often with interwoven thin fibrinous septations

  • adhesions

  • omental/mesenteric thickening

    • the greater omentum may range in appearance from striated, with bands of alternating echogenicity, to nodular and hypoechoic 

  • increased bowel wall thickness

  • lymphadenopathy 

    • early disease may demonstrate prominent mesenteric nodes with concomitant mesenteric thickening

    • commonly involves retroperitoneal, peripancreatic, and periportal nodes

    • echogenicity may be increased, or may contain a central hypoechoic focus representing caseation 8

The treatment of peritoneal tuberculosis is similar to pulmonary tuberculosis, using the following pharmacological drugs: isoniazid, rifampin, pyrazinamide, ethambutol, and streptomycin 12. Surgical procedures are necessary only in cases complicated by intestinal obstruction, bowel perforation, fistulae, abscesses, and/or hemorrhage 12.

On imaging (particularly CT), key differential considerations include:

Other less likely considerations include:

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Cases and figures

  • Case 1: tuberculous peritonitis (dry type)
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  • Case 2
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  • Case 3
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  • Case 4
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  • Case 5
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  • Case 6
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  • Case 7
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  • Case 8a: disseminated tuberculosis with perihepatic collections
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  • Case 8b: disseminated tuberculosis with necrotic lymph nodes
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  • Case 9: MRI
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  • Case 10: on ultrasound
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  • Case 11: tuberculous peritonitis and tubo-ovarian abscesses
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  • Case 12
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