Tuberculous spondylitis

Last revised by Yuranga Weerakkody on 24 May 2023

Tuberculous spondylitis, also known as Pott disease, refers to vertebral body osteomyelitis and intervertebral discitis from tuberculosis (TB). The spine is the most frequent location of musculoskeletal tuberculosis, and commonly related symptoms are back pain and lower limb weakness/paraplegia.

Tuberculous spondylitis is one of the more common infections of spine in countries where TB is prevalent. Unfortunately, the incidence of tuberculous spondylitis, as with other forms of TB, is on the rise, due to new multiple drug resistant strains.

Discitis and/or osteomyelitis comprise approximately 50% of all musculoskeletal tuberculosis, and usually affects the lower thoracic and upper lumbar levels of the spine 2.

Patients usually present with back pain, lower limb weakness/paraplegia, and kyphotic deformity. Constitutional symptoms (fever and weight loss) are also common but not as pronounced as with bacterial discitis/osteomyelitis.

The spine is involved due to hematogenous spread that can occur via both arteries and veins, resulting in different patterns of infection. 

Spread through the anterior arterial arcade that richly supplies the subchondral paradiscal bone results in infection anterosuperiorly and anteroinferior, adjacent to the disc 8. In adults and particularly older individuals the disc is conspicuously spared due to its sparse vascularity. In contrast, in younger individuals, especially children, the disc may be involved early as it has a far richer blood supply 8.  

Infection then spreads beneath the longitudinal ligaments and can lead to infection of adjacent vertebral bodies. 

Gradual anterior collapse typically results in an acute kyphotic or gibbus deformity. This angulation, coupled with epidural granulation tissue and bony fragments, can lead to cord compression.

Spread via the venous plexus of Batson typically results in infection arising centrally within the vertebral body 2,8. This is more common in older individuals. 

Gradual collapse can result in vertebra plana and acute kyphotic or gibbus deformity. This angulation, coupled with epidural granulation tissue and bony fragments, can lead to cord compression.

Posterior involvement, also known as an appendiceal pattern is also due to venous hematogenous spread via the posterior venous plexus.  

Synovial involvement is relatively rare but can be seen involving facet joints and atlantoaxial and atlanto-occipital joints. 

In late-stage spinal tuberculosis, large paraspinal abscesses can develop without severe pain or frank pus or prominent inflammatory signs and symptoms; thus "cold abscess".

The spread of infection is typically described as 'subligamentous': beneath the anterior longitudinal ligament, usually sparing the posterior elements and often involving multiple levels.

Tuberculous spondylitis can be difficult to detect in early stages because of relative preservation of the disc space.

A reduction in vertebral height is often seen with the irregularity of the anterosuperior endplate being relatively early and subtle sign. Due to the subligamentous extension, there may be some irregularity of the anterior vertebral margin. This is a classical appearance with TB spondylitis.

Later, paraspinal collections can develop which can be remarkably large.

Ivory vertebrae can result in re-ossification. Other associated features may include:

As with other extrapulmonary TB, the chest film may be unrevealing (no pulmonary lesions seen in up to 50% of cases), with the source being a primary lung lesion that is clinically silent.

Cross-sectional imaging is required to assess better the extent of involvement and particularly for the presence of an epidural component and cord compression. MRI is the modality of choice for this, with CT with contrast being a distant second.

Features include irregularity of both the endplate and anterior aspect of the vertebral bodies, with bone marrow edema and enhancement seen on MRI:

  • T1: hypointense marrow in adjacent vertebrae
  • T2: hyperintense marrow, disc, soft tissue infection
  • T1 C+ (Gd): marrow, subligamentous, discal, dural enhancement

The paraspinal collections are typically well-circumscribed, with fluid centers and well-defined enhancing margins 7.

In many parts of the developing world, TB is the most common cause of vertebral body infection, with the majority of cases seen in patients under the age of 20. TB can also affect the meninges of the spine, causing an intense pachymeningitis that enhances dramatically.

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