Tubulointerstitial nephritis

Last revised by Henry Knipe on 14 Nov 2022

Tubulointerstitial nephritis is a condition where the inflammation is mainly in or around the renal tubules. It may be acute or chronic.

Tubulointerstitial nephritis may affect any age group ranging from pediatric to adult.

Tubulointerstitial nephritis can arise from a range of causes:

  • infection

  • medications

  • autoimmune: from immunological disorders that primarily affect the kidney, e.g. anti-tubular basement membrane (anti-TBM) antibody-associated interstitial nephritis

  • genetic

  • idiopathic

  • granulomatous tubulointerstitial nephritis

  • tubulointerstitial nephritis and uveitis syndrome (TINU syndrome)

  • tubointerstitial nephritis associated with inflammatory bowel disease (IBD)

Radiographic features vary dependent on whether it is acute or chronic.

In acute stages may show delineated renal enlargement with diffuse cortical hyperechogenicity 1.

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