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At the time the article was last revised Henry Knipe had the following disclosures:
- Radiopaedia Events Pty Ltd, Speaker fees (past)
- Integral Diagnostics, Shareholder (ongoing)
- Micro-X Ltd, Shareholder (ongoing)
These were assessed during peer review and were determined to not be relevant to the changes that were made.View Henry Knipe's current disclosures
Tubulointerstitial nephritis is a condition where the inflammation is mainly in or around the renal tubules. It may be acute or chronic.
Tubulointerstitial nephritis may affect any age group ranging from pediatric to adult.
Tubulointerstitial nephritis can arise from a range of causes:
autoimmune: from immunological disorders that primarily affect the kidney, e.g. anti-tubular basement membrane (anti-TBM) antibody-associated interstitial nephritis
granulomatous tubulointerstitial nephritis
tubulointerstitial nephritis and uveitis syndrome (TINU syndrome)
tubointerstitial nephritis associated with inflammatory bowel disease (IBD)
Radiographic features vary dependent on whether it is acute or chronic.
In acute stages may show delineated renal enlargement with diffuse cortical hyperechogenicity 1.
- 1. Hiraoka M, Hori C, Tsuchida S, Tsukahara H, Sudo M. Ultrasonographic Findings of Acute Tubulointerstitial Nephritis. Am J Nephrol. 1996;16(2):154-8. doi:10.1159/000168989 - Pubmed
- 2. Joyce E, Glasner P, Ranganathan S, Swiatecka-Urban A. Tubulointerstitial Nephritis: Diagnosis, Treatment, and Monitoring. Pediatr Nephrol. 2017;32(4):577-87. doi:10.1007/s00467-016-3394-5 - Pubmed
- 3. Ruebner R & Fadrowski J. Tubulointerstitial Nephritis. Pediatr Clin North Am. 2019;66(1):111-9. doi:10.1016/j.pcl.2018.08.009 - Pubmed