Tumor necrosis factor receptor-associated periodic syndrome

Last revised by David Luong on 12 Jul 2021

Tumor necrosis factor receptor-associated periodic syndrome (or sometimes abbreviated as TRAPS) is a condition characterized by recurrent (periodic) episodes of fever as well as a spectrum of dermatologic findings that includes migratory patches, edematous plaques, periorbital edema, and/or conjunctivitis.


It is characterized by a perivascular dermal infiltrate of lymphocytes and monocytes. Its thought to be dominantly inherited mutations in TNFRSF1A, the gene encoding the 55-kDa tumor necrosis factor (TNF) receptor.

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