Tumour spread through air spaces
Last revised by Rohit Sharma on 11 Apr 2024
Citation, DOI, disclosures and article data
Citation:
Weerakkody Y, Sharma R, Di Muzio B, Tumour spread through air spaces. Reference article, Radiopaedia.org (Accessed on 29 Jun 2024) https://doi.org/10.53347/rID-69173
rID:
69173
Article created:
1 Jul 2019,
Yuranga Weerakkody ◉
Disclosures:
At the time the article was created Yuranga Weerakkody had no recorded disclosures.
View Yuranga Weerakkody's current disclosures
Last revised:
11 Apr 2024,
Rohit Sharma ◉
Disclosures:
At the time the article was last revised Rohit Sharma had no financial relationships to ineligible companies to disclose.
View Rohit Sharma's current disclosures
Revisions:
4 times, by
3 contributors -
see full revision history and disclosures
Sections:
Synonyms:
- Tumor spread through air spaces
- Tumour spread through air spaces (STAS)
- Air space invasion in lung cancer
- Spread through air spaces (STAS)
- Spread through air spaces
Tumour spread through air spaces (STAS) is a pattern of invasion in lung adenocarcinoma. According to the 2015 WHO classification, tumour spread through air spaces is defined as “micropapillary clusters, solid nests, or single cells spreading within air spaces beyond the edge of the main tumour” 2,3. Presence of tumour spread through air spaces is considered a significant risk factor of recurrence in small lung adenocarcinomas treated with limited resection.
See also
References
- 1. de Margerie-Mellon C, VanderLaan PA, Bankier AA. CT Manifestations of Tumor Spread through Air Spaces in Lung Adenocarcinoma: Different Pathways toward Common Perspectives. (2019) Radiology. 290 (1): 271-272. doi:10.1148/radiol.2018182173 - Pubmed
- 2. Kadota K, Nitadori J, Sima CS, Ujiie H, Rizk NP, Jones DR, Adusumilli PS, Travis WD. Tumor Spread through Air Spaces is an Important Pattern of Invasion and Impacts the Frequency and Location of Recurrences after Limited Resection for Small Stage I Lung Adenocarcinomas. (2015) Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 10 (5): 806-14. doi:10.1097/JTO.0000000000000486 - Pubmed
- 3. Warth A. Spread through air spaces (STAS): a comprehensive update. (2017) Translational lung cancer research. 6 (5): 501-507. doi:10.21037/tlcr.2017.06.08 - Pubmed
- 4. Kadota K, Kushida Y, Katsuki N, Ishikawa R, Ibuki E, Motoyama M, Nii K, Yokomise H, Bandoh S, Haba R. Tumor Spread Through Air Spaces Is an Independent Predictor of Recurrence-free Survival in Patients With Resected Lung Squamous Cell Carcinoma. (2017) The American journal of surgical pathology. 41 (8): 1077-1086. doi:10.1097/PAS.0000000000000872 - Pubmed
- 5. Toyokawa G, Yamada Y, Tagawa T, Kinoshita F, Kozuma Y, Matsubara T, Haratake N, Takamori S, Akamine T, Hirai F, Oda Y, Maehara Y. Significance of Spread Through Air Spaces in Resected Lung Adenocarcinomas With Lymph Node Metastasis. (2018) Clinical lung cancer. 19 (5): 395-400.e1. doi:10.1016/j.cllc.2018.04.002 - Pubmed
- 6. Liu H, Yin Q, Yang G, Qie P. Prognostic Impact of Tumor Spread Through Air Spaces in Non-small Cell Lung Cancers: a Meta-Analysis Including 3564 Patients. (2019) Pathology oncology research : POR. doi:10.1007/s12253-019-00616-1 - Pubmed
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