Tumor spread through air spaces
Citation, DOI, disclosures and article data
Citation:
Weerakkody Y, Sharma R, Di Muzio B, Tumor spread through air spaces. Reference article, Radiopaedia.org (Accessed on 07 Dec 2024) https://doi.org/10.53347/rID-69173
Permalink:
rID:
69173
Article created:
Disclosures:
At the time the article was created Yuranga Weerakkody had no recorded disclosures.
View Yuranga Weerakkody's current disclosures
Last revised:
Disclosures:
At the time the article was last revised Rohit Sharma had no financial relationships to ineligible companies to disclose.
View Rohit Sharma's current disclosures
Revisions:
4 times, by
3 contributors -
see full revision history and disclosures
Sections:
Synonyms:
- Tumor spread through air spaces
- Tumour spread through air spaces (STAS)
- Air space invasion in lung cancer
- Spread through air spaces (STAS)
- Spread through air spaces
Tumor spread through air spaces (STAS) is a pattern of invasion in lung adenocarcinoma. According to the 2015 WHO classification, tumor spread through air spaces is defined as “micropapillary clusters, solid nests, or single cells spreading within air spaces beyond the edge of the main tumor” 2,3. Presence of tumor spread through air spaces is considered a significant risk factor of recurrence in small lung adenocarcinomas treated with limited resection.
See also
References
- 1. de Margerie-Mellon C, VanderLaan PA, Bankier AA. CT Manifestations of Tumor Spread through Air Spaces in Lung Adenocarcinoma: Different Pathways toward Common Perspectives. (2019) Radiology. 290 (1): 271-272. doi:10.1148/radiol.2018182173 - Pubmed
- 2. Kadota K, Nitadori J, Sima CS, Ujiie H, Rizk NP, Jones DR, Adusumilli PS, Travis WD. Tumor Spread through Air Spaces is an Important Pattern of Invasion and Impacts the Frequency and Location of Recurrences after Limited Resection for Small Stage I Lung Adenocarcinomas. (2015) Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 10 (5): 806-14. doi:10.1097/JTO.0000000000000486 - Pubmed
- 3. Warth A. Spread through air spaces (STAS): a comprehensive update. (2017) Translational lung cancer research. 6 (5): 501-507. doi:10.21037/tlcr.2017.06.08 - Pubmed
- 4. Kadota K, Kushida Y, Katsuki N, Ishikawa R, Ibuki E, Motoyama M, Nii K, Yokomise H, Bandoh S, Haba R. Tumor Spread Through Air Spaces Is an Independent Predictor of Recurrence-free Survival in Patients With Resected Lung Squamous Cell Carcinoma. (2017) The American journal of surgical pathology. 41 (8): 1077-1086. doi:10.1097/PAS.0000000000000872 - Pubmed
- 5. Toyokawa G, Yamada Y, Tagawa T, Kinoshita F, Kozuma Y, Matsubara T, Haratake N, Takamori S, Akamine T, Hirai F, Oda Y, Maehara Y. Significance of Spread Through Air Spaces in Resected Lung Adenocarcinomas With Lymph Node Metastasis. (2018) Clinical lung cancer. 19 (5): 395-400.e1. doi:10.1016/j.cllc.2018.04.002 - Pubmed
- 6. Liu H, Yin Q, Yang G, Qie P. Prognostic Impact of Tumor Spread Through Air Spaces in Non-small Cell Lung Cancers: a Meta-Analysis Including 3564 Patients. (2019) Pathology oncology research : POR. doi:10.1007/s12253-019-00616-1 - Pubmed
Incoming Links
Articles:
Related articles: Chest
- imaging techniques
-
chest radiograph
- radiography
-
approach
- ABCDE
- ABCDEFGHI
- congenital heart disease
- medical devices in the thorax
- common lines and tubes
- nasogastric tubes
- endotracheal tubes
- central venous catheters
- esophageal temperature probe
- tracheostomy tube
- pleural catheters
- cardiac conduction devices
- prosthetic heart valve
- review areas
-
airspace opacification
- differential diagnoses of airspace opacification
- lobar consolidation
-
atelectasis
- mechanism-based
- morphology-based
- lobar lung collapse
- chest x-ray in the exam setting
- cardiomediastinal contour
- chest radiograph zones
- tracheal air column
- fissures
- normal chest x-ray appearance of the diaphragm
- nipple shadow
-
lines and stripes
- anterior junction line
- posterior junction line
- right paratracheal stripe
- left paratracheal stripe
- posterior tracheal stripe/tracheo-esophageal stripe
- posterior wall of bronchus intermedius
- right paraspinal line
- left paraspinal line
- aortic-pulmonary stripe
- aortopulmonary window
- azygo-esophageal recess
- spaces
- signs
- air bronchogram
- big rib sign
- Chang sign
- Chen sign
- coin lesion
- continuous diaphragm sign
- dense hilum sign
- double contour sign
- egg-on-a-string sign
- extrapleural sign
- finger in glove sign
- flat waist sign
- Fleischner sign
- ginkgo leaf sign
- Golden S sign
- Hampton hump
- haystack sign
- hilum convergence sign
- hilum overlay sign
- Hoffman-Rigler sign
- holly leaf sign
- incomplete border sign
- juxtaphrenic peak sign
- Kirklin sign
- medial stripe sign
- melting ice cube sign
- more black sign
- Naclerio V sign
- Palla sign
- pericardial fat tag sign
- Shmoo sign
- silhouette sign
- snowman sign
- spinnaker sign
- steeple sign
- straight left heart border sign
- third mogul sign
- tram-track sign
- walking man sign
- water bottle sign
- wave sign
- Westermark sign
- HRCT
-
chest radiograph
- airways
- bronchitis
- small airways disease
-
bronchiectasis
- broncho-arterial ratio
- related conditions
- differentials by distribution
- narrowing
-
tracheal stenosis
- diffuse tracheal narrowing (differential)
-
bronchial stenosis
- diffuse airway narrowing (differential)
-
tracheal stenosis
- diverticula
- pulmonary edema
-
interstitial lung disease (ILD)
- Anti-Jo-1 antibody-positive interstitial lung disease
- drug-induced interstitial lung disease
-
hypersensitivity pneumonitis
- acute hypersensitivity pneumonitis
- subacute hypersensitivity pneumonitis
- chronic hypersensitivity pneumonitis
- etiology
- bird fancier's lung: pigeon fancier's lung
- farmer's lung
- cheese workers' lung
- bagassosis
- mushroom worker’s lung
- malt worker’s lung
- maple bark disease
- hot tub lung
- wine maker’s lung
- woodsman’s disease
- thatched roof lung
- tobacco grower’s lung
- potato riddler’s lung
- summer-type pneumonitis
- dry rot lung
- machine operator’s lung
- humidifier lung
- shower curtain disease
- furrier’s lung
- miller’s lung
- lycoperdonosis
- saxophone lung
-
idiopathic interstitial pneumonia (mnemonic)
- acute interstitial pneumonia (AIP)
- cryptogenic organizing pneumonia (COP)
- desquamative interstitial pneumonia (DIP)
- non-specific interstitial pneumonia (NSIP)
- idiopathic pleuroparenchymal fibroelastosis
- lymphoid interstitial pneumonia (LIP)
- respiratory bronchiolitis–associated interstitial lung disease (RB-ILD)
- usual interstitial pneumonia / idiopathic pulmonary fibrosis (UIP/IPF)
-
pneumoconioses
- fibrotic
- non-fibrotic
-
lung cancer
-
non-small-cell lung cancer
-
adenocarcinoma
- pre-invasive tumors
- minimally invasive tumors
- invasive tumors
- variants of invasive carcinoma
- described imaging features
- adenosquamous carcinoma
- large cell carcinoma
- primary sarcomatoid carcinoma of the lung
- squamous cell carcinoma
- salivary gland-type tumors
-
adenocarcinoma
- pulmonary neuroendocrine tumors
- preinvasive lesions
-
lung cancer invasion patterns
- tumor spread through air spaces (STAS)
- presence of non-lepidic patterns such as acinar, papillary, solid, or micropapillary
- myofibroblastic stroma associated with invasive tumor cells
- pleural invasion
- vascular invasion
- tumors by location
- benign neoplasms
- pulmonary metastases
- lung cancer screening
- lung cancer staging
-
non-small-cell lung cancer
Unable to process the form. Check for errors and try again.