Undifferentiated carcinoma of the endometrium
Last revised by David Luong
on 18 Jun 2021
Citation, DOI, disclosures and article data
Citation:
Luong D, Mudgal P, Undifferentiated carcinoma of the endometrium. Reference article, Radiopaedia.org (Accessed on 23 Jan 2025) https://doi.org/10.53347/rID-18160
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rID:
18160
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Disclosures:
At the time the article was created Yuranga Weerakkody had no recorded disclosures.
View Yuranga Weerakkody's current disclosures
Last revised:
18 Jun 2021,
David Luong
Disclosures:
At the time the article was last revised David Luong had no recorded disclosures.
View David Luong's current disclosures
Revisions:
2 times, by
2 contributors -
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Systems:
Synonyms:
- Undifferentiated endometrial carcinoma
- Undifferentiated carcinoma of endometrium
- Undifferentiated endometrial cancer
Undifferentiated carcinoma of the endometrium a is rare histological subtype of endometrial cancer. It is considered a high grade carcinoma, carries a poor prognosis and is often under-recognized 1.
Epidemiology
It is thought to represent approximately 1-9% of endometrial cancers 1,6.
Pathology
They have no evidence of glandular or epithelial differentiation. They can be further subdivided into large cell, intermediate or small cell types. Some carcinomas carry neuroendocrine expression 4.
References
- 1. Silva EG, Deavers MT, Malpica A. Undifferentiated carcinoma of the endometrium: a review. Pathology. 2007;39 (1): 134-8. doi:10.1080/00313020601159494 - Pubmed citation
- 2. Altrabulsi B, Malpica A, Deavers MT et-al. Undifferentiated carcinoma of the endometrium. Am. J. Surg. Pathol. 2005;29 (10): 1316-21. Am. J. Surg. Pathol. (link) - Pubmed citation
- 3. Hayashi M, Ueda Y, Takimoto T et-al. Undifferentiated endometrial carcinoma of the uterus: marked effect of chemotherapy with tetrahydropyranyl-adriamycin, paclitaxel, and carboplatin. Int. J. Gynecol. Cancer. 14 (2): 388-94. doi:10.1111/j.1048-891x.2004.014228.x - Pubmed citation
- 4. Huntsman DG, Clement PB, Gilks CB et-al. Small-cell carcinoma of the endometrium. A clinicopathological study of sixteen cases. Am. J. Surg. Pathol. 1994;18 (4): 364-75. - Pubmed citation
- 5. Wells M, Fox H, Buckley CH et-al. Gynaecological and Obstetric Pathology for the MRCOG and Beyond. (2009) ISBN:1904752764. Read it at Google Books - Find it at Amazon
- 6. Jiménez-Ayala M, Portillo BJ. Endometrial adenocarcinoma, prevention and early diagnosis. S Karger Ag. (2008) ISBN:3805584806. Read it at Google Books - Find it at Amazon
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