Undifferentiated carcinoma of the endometrium is rare histological subtype of endometrial cancer. It is considered a high grade carcinoma, carries a poor prognosis and is often under-recognised 1.
It is thought to represent approximately 1-9% of endometrial cancers 1,6.
They have no evidence of glandular or epithelial differentiation. They can be further sub divided into large cell, intermediate or small cell types. Some of carcinomas carry neuroendocrine expression 4.
- 1. Silva EG, Deavers MT, Malpica A. Undifferentiated carcinoma of the endometrium: a review. Pathology. 2007;39 (1): 134-8. doi:10.1080/00313020601159494 - Pubmed citation
- 2. Altrabulsi B, Malpica A, Deavers MT et-al. Undifferentiated carcinoma of the endometrium. Am. J. Surg. Pathol. 2005;29 (10): 1316-21. Am. J. Surg. Pathol. (link) - Pubmed citation
- 3. Hayashi M, Ueda Y, Takimoto T et-al. Undifferentiated endometrial carcinoma of the uterus: marked effect of chemotherapy with tetrahydropyranyl-adriamycin, paclitaxel, and carboplatin. Int. J. Gynecol. Cancer. 14 (2): 388-94. doi:10.1111/j.1048-891x.2004.014228.x - Pubmed citation
- 4. Huntsman DG, Clement PB, Gilks CB et-al. Small-cell carcinoma of the endometrium. A clinicopathological study of sixteen cases. Am. J. Surg. Pathol. 1994;18 (4): 364-75. - Pubmed citation
- 5. Wells M, Fox H, Buckley CH et-al. Gynaecological and Obstetric Pathology for the MRCOG and Beyond. (2009) ISBN:1904752764. Read it at Google Books - Find it at Amazon
- 6. Jiménez-Ayala M, Portillo BJ. Endometrial adenocarcinoma, prevention and early diagnosis. S Karger Ag. (2008) ISBN:3805584806. Read it at Google Books - Find it at Amazon