Unilateral axillary lymphadenopathy (differential)

Changed by Daniel J Bell, 4 Feb 2021
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Unilateral axillary lymphadenopathy while being more concerning than bilateral axillary lymphadenopathy can still arise from a variety of benign, as well as malignant, causes.

Benign
Malignant
  • metastasis from breast malignancy
  • metastasis from non-breast malignancies
    • melanoma: a relatively common non-breast primary malignancy to present with axillary lymphadenopathy
    • primary malignancy in ipsilateral arm
  • lymphoma: can occasionally be unilateral

See also

  • -<p><strong>Unilateral axillary lymphadenopathy</strong> while being more concerning than <a title="Bilateral axillary lymphadenopathy (differential)" href="/articles/bilateral-axillary-lymphadenopathy-differential">bilateral axillary lymphadenopathy</a> can still arise from a variety of benign, as well as malignant, causes.</p><h5>Benign</h5><ul>
  • +<p><strong>Unilateral axillary lymphadenopathy</strong> while being more concerning than <a href="/articles/bilateral-axillary-lymphadenopathy-differential">bilateral axillary lymphadenopathy</a> can still arise from a variety of benign, as well as malignant, causes.</p><h5>Benign</h5><ul>
  • -<li>ipsilateral arm infection, e.g. <a title="Cellulitis" href="/articles/cellulitis">cellulitis</a>
  • +<li>ipsilateral arm infection, e.g. <a href="/articles/cellulitis">cellulitis</a>
  • +<li>
  • +<a href="/articles/vaccination">post-vaccination</a>: described for both <a href="/articles/influenza">influenza</a> and <a href="/articles/covid-19-4">COVID-19</a> vaccines, usually self-limiting <sup>4,5</sup>
  • +</li>

References changed:

  • 4. Shirone N, Shinkai T, Yamane T, Uto F, Yoshimura H, Tamai H, Imai T, Inoue M, Kitano S, Kichikawa K, Hasegawa M. Axillary lymph node accumulation on FDG-PET/CT after influenza vaccination. (2012) Annals of nuclear medicine. 26 (3): 248-52. <a href="https://doi.org/10.1007/s12149-011-0568-x">doi:10.1007/s12149-011-0568-x</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/22271546">Pubmed</a> <span class="ref_v4"></span>
  • 5. Mehta N, Sales RM, Babagbemi K, Levy AD, McGrath AL, Drotman M, Dodelzon K. Unilateral axillary Adenopathy in the setting of COVID-19 vaccine. (2021) Clinical imaging. 75: 12-15. <a href="https://doi.org/10.1016/j.clinimag.2021.01.016">doi:10.1016/j.clinimag.2021.01.016</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/33486146">Pubmed</a> <span class="ref_v4"></span>

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