Ureteritis cystica

Ureteritis cystica or pyeloureteritis cystica is a benign condition of the ureters representing multiple small submucosal cysts. 

Typically this condition is seen in diabetics, with recurrent urinary tract infection. As such is is most frequently seen in older patients and is more common in women.

Aetiology

Ureteritis cystica results from chronic urinary tract irritation due to stones and/or infection. Organisms frequently involved include:

  • E. coli (most common)
  • M. tuberculosis
  • Enterococcus
  • Proteus spp.
  • Schistosomiasis
Histology

Histologically there are numerous small submucosal epithelial-lined cysts representing cystic degeneration of metaplastic epithelium or submucosal Brunn cell nests 1-3. Their walls are transparent macroscopically, and the fluid contained within is mucoproteinacous. There is often a surrounding infiltrate of lymphocytes 4

Whether imaged with conventional intravenous excretory urography or more recently with a CT urogram, the appearance is that of multiple small 2-5 mm smooth walled rounded lucent filling defects projecting into the lumen, usually of the ureter. Rarely they can be up to 2-3 cm in size 2,4.

They are most common in the proximal ureter, but can be seen anywhere along the urinary tract: bladder (cystitis cystica) or renal pelvis (pyelitis cystica). The condition occurs bilaterally in up to 50% of cases 4

Usually, no treatment is required for ureteritis cystica per se, but rather the underlying cause of chronic infection may need treatment, e.g. nephrolithiasis. In such cases, the condition may resolve. Often, when no treatable underlying condition is present, the appearance remains stable over time 4

There is perhaps an increased incidence of formation of transitional cell carcinoma (TCC) 5, although this may relate to the common underlying cause of chronic inflammation rather than the disease itself 6,8.  

The first to report of this entity was Morgagni in the late 18th century 7. The first to describe it were Richmond and Robb 5.

The differential is that of multiple filling defects of the ureter and includes:

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Article Information

rID: 8554
System: Urogenital
Section: Pathology
Tag: ureter
Synonyms or Alternate Spellings:
  • Pyeloureteritis cystica
  • Cystic degeneration of the urethral mucosa
  • Pyelourethral bullous dystrophy

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