Uterine lipoleiomyoma

Last revised by Mostafa El-Feky on 4 Mar 2023

Uterine lipoleiomyomas result from degeneration of smooth muscle cells in an ordinary leiomyoma and represent a rare benign tumor of the uterus 1.

Lipoleiomyomas have a reported incidence of 0.03-0.20% and are typically found in postmenopausal patients with typical uterine leiomyomas 2.

Although most patients are asymptomatic, they can present with symptoms similar to leiomyomas of the same size and location. Symptoms include, but are not limited to, abdominal/pelvic pain, palpable mass, and menstrual abnormalities.

Many considered uterine lipoleiomyoma as a distinct variety of leiomyoma. Histologically, it is composed of variable amounts of adipocytes and smooth muscle cells, separated by thin fibrous tissue. The exact etiology is not well known but is thought to represent fatty metaplasia of the smooth muscle cells of a leiomyoma. Lesions can vary in size from a few millimeters to a few centimeters.

Advanced imaging of these lesions allows for differentiation from cystic ovarian neoplasms, which may require surgical therapy 3.

  • hyperechoic with a partially hypoechoic rim
    • the rim likely represents a layer of myometrium surrounding the fatty central component 3
  • posterior acoustic attenuation
  • often poor vascularity on color Doppler examination
  • predominantly fat-containing mass arising from uterus
  • well-marginated 
  • often contains areas of soft tissue density

Secondary to the predominant fatty component in the lesion, hyperintensity is seen on T1 weighted sequences and chemical shift artifacts are noted. Additionally, fat suppression techniques can be useful in verifying the diagnosis - most of the lesion shows fat suppression 3. Signal characteristics are, therefore:

  • T1: hyperintensity
  • T1 FS: hypointensity (saturates out)
  • T2: hyperintensity
  • T2 FS or STIR: hypointensity (saturates out)

Lipoleiomyomas when small and asymptomatic usually do not require treatment and are clinically similar to leiomyomas. Treatment is similar to leiomyomas and is dependent on the clinical symptoms and the size/location of the lesion. Uterine artery embolization or surgical excision can be performed, as indicated 1. In general, they are benign tumors with favorable prognosis. 

The first report as a "myolipoma of soft tissue" was thought to have been described in 1991 by Meis and Enzinger 4.

General imaging differential considerations include:

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Cases and figures

  • Case 1
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  • Case 2
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  • Case 3
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  • Case 4: lipoleiomyoma of the uterus
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  • Case 5a: ultrasound
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  • Case 5b: MRI
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  • Case 6a: CT
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  • Case 6b: T1C+ fat sat (MRI)
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  • Case 7
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