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Uterus didelphys

Uterus didelphys is a type of Müllerian duct anomaly (class III) where there is a complete duplication of uterine horns as well as duplication of the cervix, with no communication between them.  

Didelphic uteri account for approximately ~8% (range 5-11%) of Müllerian duct anomalies.

Many patients are asymptomatic although some may occasionally experience dyspareunia as a result of the vaginal septum.

It results from failed ductal fusion that occurs between the 12th and 16th week of pregnancy and is characterized by two symmetric, widely divergent uterine horns and two cervices. The uterine volume in each duplicated segment is reduced. As with most uterine anatomical anomalies, there is an increased incidence of fertility issues, and Müllerian abnormalities, in general, are over-represented in infertile women. The chance of seeing a pregnancy to term is significantly reduced, down to only 20%, with a third of pregnancies ending in abortion and over half in premature deliveries. Only 40% of pregnancies resulted in living children 2

Along with unicornuate uterus, uterus didelphys has the greatest impact on reproductive performance reference required

Classically shows two widely spaced uterine corpora, each with a single Fallopian tube. Separate divergent uterine horns with large fundal cleft (as distinct from a septate uterus)

Uterus didelphys should be differentiated from a bicornuate uterus (separation of horns only) and a septate uterus (midline uterine septum).

HSG demonstrates two separate endocervical canals that open into separate fusiform endometrial cavities, with no communication between the two horns. Each endometrial cavity ends in a solitary fallopian tube.

If the anomaly is associated with an obstructed longitudinal vaginal septum, only one cervical os may be depicted, and it may be cannulated with the endometrial configuration mimicking a unicornuate uterus.

Separate divergent uterine horns are identified with a large fundal cleft. Endometrial cavities are uniformly separate, with no evidence of communication. Two separate cervices need to be documented.

MR imaging demonstrates two separate uteri with widely divergent apices, two separate cervices, and usually an upper vaginal longitudinal septum. In each uterus, normal uterine zonal anatomy is preserved.

Anatomy: Abdominopelvic

Anatomy: Abdominopelvic

Article information

rID: 2248
System: Gynaecology
Synonyms or Alternate Spellings:
  • Uterine didelphys
  • Didelphic uterus
  • Double uterus with double cervix

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Cases and figures

  • Figure 1
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  • Case 1
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  • Case 2: with tuboovarian abscess
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  • Case 3: with leiomyoma in right horn
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  • Case 4: with concurrent endometriosis
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  •  Case 5
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  • Case 6
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  • Case 7: with obstructed hemivagina
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  • Case 8
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  • Case 9: with Herlyn-Werner-Wunderlich syndrome
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  • Case 10
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  • Case 11
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  • Case 12
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  • Case 13
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  • Case 14
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