Van der Woude syndrome

van der Woude syndrome (VWS) is characterized by the association of congenital lower lip fistulae / pits with cleft lip and / or palate.

It is one of the most common clefting syndromes in humans 1.  VWS individuals have a high prevalence of hypodontia.



It carries anautosomal dominant inheritance. Although caused by a single gene mutation, VWS has variable phenotypic expression.

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Article information

rID: 15163
System: Head & Neck
Section: Syndromes
Synonyms or Alternate Spellings:
  • Van der Woude syndrome (VWS)

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