van der Woude syndrome (VWS) is characterized by the association of congenital lower lip fistulae/pits with cleft lip and/or palate.
It is one of the most common clefting syndromes in humans 1 and affected individuals have a high prevalence of hypodontia.
It carries an autosomal dominant inheritance. Although caused by a single gene mutation, Van der Woude syndrome has variable phenotypic expression.
- 1. Lam AK, David DJ, Townsend GC et-al. Van der Woude syndrome: dentofacial features and implications for clinical practice. Aust Dent J. 2010;55 (1): 51-8. doi:10.1111/j.1834-7819.2009.01178.x - Pubmed citation
- 2. King NM, Cheong CH, Sanares AM. Van der Woude syndrome: a report of two cases. J Clin Pediatr Dent. 2004;28 (3): 267-71. - Pubmed citation
- 3. Rizos M, Spyropoulos MN. Van der Woude syndrome: a review. Cardinal signs, epidemiology, associated features, differential diagnosis, expressivity, genetic counselling and treatment. Eur J Orthod. 2004;26 (1): 17-24. Eur J Orthod (link) - Pubmed citation