Citation, DOI, disclosures and article data
Citation:
Luong D, Bell D, Lauder J, et al. Van der Woude syndrome. Reference article, Radiopaedia.org (Accessed on 15 Jan 2025) https://doi.org/10.53347/rID-15163
Van der Woude syndrome (VWS) is characterized by the association of congenital lower lip fistulae/pits with cleft lip and/or palate.
It is one of the most common clefting syndromes in humans 1 and affected individuals have a high prevalence of hypodontia.
Pathology
Genetics
It carries an autosomal dominant inheritance. Although caused by a single gene mutation, Van der Woude syndrome has variable phenotypic expression.
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1. Lam AK, David DJ, Townsend GC et-al. Van der Woude syndrome: dentofacial features and implications for clinical practice. Aust Dent J. 2010;55 (1): 51-8. doi:10.1111/j.1834-7819.2009.01178.x - Pubmed citation
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2. King NM, Cheong CH, Sanares AM. Van der Woude syndrome: a report of two cases. J Clin Pediatr Dent. 2004;28 (3): 267-71. - Pubmed citation
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3. Rizos M, Spyropoulos MN. Van der Woude syndrome: a review. Cardinal signs, epidemiology, associated features, differential diagnosis, expressivity, genetic counselling and treatment. Eur J Orthod. 2004;26 (1): 17-24. Eur J Orthod (link) - Pubmed citation
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